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Targeted Allele Detail
Symbol: Vav3tm1Swat
Name: vav 3 oncogene; targeted mutation 1, Wojciech Swat
MGI ID: MGI:2683642
Gene: Vav3  Location: Chr3:109247969-109593014 bp, + strand  Genetic Position: Chr3, 48.13 cM, cytoband G1
Alliance: Vav3tm1Swat page
Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat mice develop buphthalmos

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:86654
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 10 was replaced with a floxed neomycin selection cassette inserted by homologous recombination. The deleted region encoded a portion of the Dbl homology domain. Neither full length nor truncated protein was detected by Western blot analysis of splenocytes obtained from homozygous mutant mice. (J:86654, J:97055)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vav3 Mutation:  32 strains or lines available
Original:  J:86654 Fujikawa K, et al., Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003 Nov 17;198(10):1595-608
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory