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Phenotype Image Detail
Caption Eyes of Vav2tm1Kdf/Vav2tm1Kdf Vav3tm1Swat/Vav3tm1Swat (Vav2-/- Vav3-/-) mice develop buphthalmos between 6 and 12 weeks of age. A. Left photo: Representative photo of unilateral enlarged eye in 10 week old mutant mice. Center photo: Representative photo of bilateral enlarged eyes in 16 week old mutant mice. Right photo: Representative photo of enlarged eye becoming atrophic in 8 week old mutant mice. B. Comparison of eye sizes. Left panel: Representative eye of 10 week old wild-type (WT) mice as a control (n = 20). Cornea diameter is 2.9 +/- 0.1 mm. Weight is 15.8 +/- 1.1 mg. Center panel: Representative first-recognized enlarged eye of mutant mice (9- to 10-week old, n = 20). The cornea diameter is 3.3 +/- 0.1 mm. Weight is 23.7 +/- 4.4 mg. P<0.0001. Right panel: Representative moderately enlarged eye of 12 week old mutant mice (n = 20). The cornea diameter is 4.2 +/- 0.4 mm. Weight is 38.0 +/- 4.0 mg. C. Age of onset of enlarged eyes up to 25 weeks of age in mutant mice (n = 200). The vertical axis is a cumulative percentage of mutant mice with enlargement of the eyes.
Copyright This image is from Fujikawa K, PLoS One 2010;5(2):e9050, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:158008
Symbol Name
Vav2tm1Kdf vav 2 oncogene; targeted mutation 1, Klaus-Dieter Fischer
Vav3tm1Swat vav 3 oncogene; targeted mutation 1, Wojciech Swat
Allelic Composition Genetic Background
B6.129S-Vav2tm1Kdf Vav3tm1Swat

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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