Vav1^tm1Tyb
Targeted Allele Detail

Summary

• Symbol: Vav1^tm1Tyb
• Name: vav 1 oncogene; targeted mutation 1, Victor L J Tybulewicz
• MGI ID: MGI:2387838
• Synonyms: Vav-, Vav1-
• Gene: Vav1 Location: Chr17:57586100-57635031 bp, + strand Genetic Position: Chr17, 29.76 cM
• Alliance: Vav1^tm1Tyb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79323
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into a coding exon at nucleotide 793. No full-length or partial protein product was detectable in thymocytes and splenic B and T cells from homozygous mutant animals via Western blot analysis. (J:79324, J:97055)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Vav1 Mutation: 58 strains or lines available

References

• Original: J:79323 Turner M, et al., A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes. Immunity. 1997 Oct;7(4):451-60
• All: 87 reference(s)