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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Shc1
src homology 2 domain-containing transforming protein C1
MGI:98296
46 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Myl1tm1(cre)Sjb/Myl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ 		abnormal locomotor coordination J:122927
ataxia J:122927
decreased muscle spindle number J:122927
impaired limb coordination J:122927
Shc1tm1Lex/Shc1tm1Lex
involves: 129S5/SvEvBrd * C57BL/6J 		preweaning lethality, complete penetrance J:103485
Shc1tm1Paw/Shc1tm1Paw
either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1) 		abnormal actin cytoskeleton morphology J:62182
abnormal atrioventricular cushion morphology J:62182
abnormal blood vessel morphology J:62182
abnormal carotid artery morphology J:62182
abnormal cell adhesion J:62182
abnormal cell morphology J:62182
abnormal cell physiology J:62182
abnormal heart left ventricle morphology J:62182
abnormal vascular endothelial cell morphology J:62182
abnormal vascular smooth muscle morphology J:62182
abnormal vein morphology J:62182
abnormal vitelline vasculature morphology J:62182
atrioventricular cushion hypoplasia J:62182
decreased angiogenesis J:62182
decreased cardiac muscle contractility J:62182
decreased heart left ventricle wall thickness J:62182
embryonic lethality during organogenesis, complete penetrance J:62182
enlarged pericardium J:62182
heart vascular congestion J:62182
pale yolk sac J:62182
thin myocardium J:62182
trabecula carnea hypoplasia J:62182
vascular smooth muscle hypoplasia J:62182
Shc1tm1Pgp/Shc1tm1Pgp
involves: 129 		atherosclerotic lesions J:81977
decreased cellular sensitivity to hydrogen peroxide J:58535, J:81977
decreased cellular sensitivity to oxidative stress J:58535
decreased cellular sensitivity to ultraviolet irradiation J:58535, J:81977
decreased susceptibility to atherosclerosis J:81977
extended life span J:58535
normal growth/size/body region phenotype J:58535
normal homeostasis/metabolism phenotype J:81977
increased vasodilation J:81977
oxidative stress J:81977
Shc1tm1Ravi/Shc1tm1Ravi
Tg(Lck-cre)1Cwi/?
involves: 129 * C57BL/6 		abnormal double-negative T cell morphology J:78180
decreased double-positive T cell number J:78180
decreased single-positive T cell number J:78180
thymus hypoplasia J:78180
Shc1tm1Ravi/Shc1tm1Ravi
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		decreased body weight J:111058
decreased brain size J:111058
Shc1tm2Paw/Shc1tm2Paw
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:122927
Shc1tm8Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:122927
Shc1tm8Paw/Shc1tm9.1Paw
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		embryonic lethality during organogenesis, incomplete penetrance J:122927
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory