69 phenotypes from 11 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cd19tm1(cre)Cgn/Cd19+ Pax5tm1Mbu/Pax5tm3Mbu involves: 129P2/OlaHsd * 129S2/SvPas	abnormal B cell differentiation	J:75504
	abnormal class switch recombination	J:75504
	decreased IgG1 level	J:75504
	decreased IgG3 level	J:75504
	decreased IgG level	J:75504
	decreased immature B cell number	J:75504
	decreased immunoglobulin level	J:75504
	decreased mature B cell number	J:75504
	decreased pre-B cell number	J:75504
Pax5m1Btlr/Pax5m1Btlr C57BL/6J-Pax5m1Btlr	decreased B cell number	J:220072
	decreased IgA level	J:220072
	decreased IgG1 level	J:220072
	decreased IgG2a level	J:220072
	decreased IgG2b level	J:220072
	decreased IgG level	J:220072
	decreased IgM level	J:220072
	impaired humoral immune response	J:220072
	increased macrophage cell number	J:220072
	increased monocyte cell number	J:220072
	increased single-positive T cell number	J:220072
	increased T cell number	J:220072
Pax5m2Btlr/Pax5+ C57BL/6J-Pax5m2Btlr	decreased B-1b cell number	J:254824
Pax5m2Btlr/Pax5m2Btlr C57BL/6J-Pax5m2Btlr	decreased B-1b cell number	J:254824
	increased B-1 B cell number	J:254824
Pax5m3Btlr/Pax5+ C57BL/6J-Pax5m3Btlr	decreased B cell number	J:254825
Pax5m3Btlr/Pax5m3Btlr C57BL/6J-Pax5m3Btlr	abnormal humoral immune response	J:254825
	decreased B cell number	J:254825
	decreased B-1 B cell number	J:254825
	decreased IgG level	J:254825
	decreased IgM level	J:254825
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:254825
	increased CD8-positive, alpha-beta memory T cell number	J:254825
Pax5m4Btlr/Pax5m4Btlr C57BL/6J-Pax5m4Btlr	decreased IgD level	J:265140
Pax5M5Btlr/Pax5M5Btlr C57BL/6J-Pax5M5Btlr	decreased IgD level	J:265141
Pax5tm1b(EUCOMM)Wtsi/Pax5+ C57BL/6N-Pax5tm1b(EUCOMM)Wtsi/Ieg	abnormal auditory brainstem response	J:211773
	decreased leukocyte cell number	J:211773
	hyperactivity	J:211773
	immune system phenotype	J:211773
	impaired glucose tolerance	J:211773
	increased CD4-positive NK T cell number	J:211773
	increased circulating amylase level	J:211773
	increased circulating lipase level	J:211773
	increased circulating triglyceride level	J:211773
	increased memory-marker CD4-positive NK T cell number	J:211773
Pax5tm1b(EUCOMM)Wtsi/Pax5tm1b(EUCOMM)Wtsi C57BL/6N-Pax5tm1b(EUCOMM)Wtsi/Ieg	preweaning lethality, complete penetrance	J:211773
Pax5tm1Mbu/Pax5+ involves: 129S2/SvPas * C57BL/6	abnormal cerebellar lobule formation	J:113076
	abnormal cerebellum morphology	J:113076
Pax5tm1Mbu/Pax5tm1Mbu either: 129 or (involves: 129S2/SvPas * C57BL/6J)	abnormal late pro-B cell	J:21935
	abnormal lymphopoiesis	J:21935
	absent late pro-B cells	J:21935
	arrested B cell differentiation	J:21935
Pax5tm1Mbu/Pax5tm1Mbu involves: 129S2/SvPas	abnormal B cell physiology	J:123629
	abnormal cell adhesion	J:123629
	abnormal cell migration	J:123629
	abnormal immunoglobulin heavy chain V(D)J recombination	J:139510
	arrested B cell differentiation	J:75504
	lethality at weaning, complete penetrance	J:75504
	postnatal growth retardation	J:75504
Pax5tm1Mbu/Pax5tm1Mbu involves: 129S2/SvPas * C57BL/6	abnormal B cell differentiation	J:38813
	abnormal cerebellar foliation	J:113076
	abnormal cerebellum morphology	J:113076
	abnormal cerebellum vermis morphology	J:113076
	abnormal hindbrain development	J:113076
	abnormal lymphopoiesis	J:38813
	absent B-2 B cells	J:113076
	absent mature B cells	J:113076
	arrested B cell differentiation	J:113076
	decreased B cell number	J:113076
	decreased B-1 B cell number	J:113076
	decreased body size	J:113076
	decreased body weight	J:113076
	decreased immature B cell number	J:113076
	decreased immunoglobulin level	J:113076
	decreased inferior colliculus size	J:113076
	normal hearing/vestibular/ear phenotype	J:113076
	increased T cell number	J:113076
	limb grasping	J:113076
	postnatal lethality, incomplete penetrance	J:113076
	premature death	J:113076
Pax5tm1Mbu/Pax5tm3Mbu Tg(Mx1-cre)1Cgn/? involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA	decreased mature B cell number	J:75504
Pax5tm3.1Mbu/Pax5tm3.1Mbu involves: 129P2/OlaHsd * C57BL/6	arrested B cell differentiation	J:75504
	lethality at weaning, complete penetrance	J:75504
	postnatal growth retardation	J:75504
Pax5tm3Mbu/Pax5+ Tg(Gad1-cre,-lacZ)1Mini/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	dilated lateral ventricle	J:195054
	domed cranium	J:195054
	hydrocephaly	J:195054
	increased anxiety-related response	J:195054
	increased locomotor activity	J:195054
	premature death	J:195054
Pax5tm3Mbu/Pax5tm3Mbu involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:75504
Pax5tm3Mbu/Pax5tm3Mbu Tg(Gad1-cre,-lacZ)1Mini/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal cerebral cortex morphology	J:195054
	dilated lateral ventricle	J:195054
	domed cranium	J:195054
	hydrocephaly	J:195054
	increased anxiety-related response	J:195054
	increased locomotor activity	J:195054
	premature death	J:195054
Pax5tm5Mbu/Pax5tm5Mbu B6.129P2-Pax5tm5Mbu	normal immune system phenotype	J:144100
Pax5tm6.1Mbu/Pax5tm6.1Mbu B6.129P2-Pax5tm6.1Mbu	normal immune system phenotype	J:173158