Pax5^tm6.1Mbu
Targeted Allele Detail

Summary

• Symbol: Pax5^tm6.1Mbu
• Name: paired box 5; targeted mutation 6.1, Meinrad Busslinger
• MGI ID: MGI:4941325
• Synonyms: Pax5^Bio
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^tm6.1Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168973
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A biotin acceptor sequence was inserted at the C-terminus and an IRES-birA expression cassette was inserted into the 3'UTR. A floxed puro cassette used for selection was removed by cre-mediated recombination. (J:168973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 35 strains or lines available

References

• Original: J:168973 Ebert A, et al., The distal v(h) gene cluster of the igh locus contains distinct regulatory elements with pax5 transcription factor-dependent activity in pro-B cells. Immunity. 2011 Feb 25;34(2):175-87
• All: 4 reference(s)