Pax5^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pax5^m2Btlr
• Name: paired box 5; mutation 2, Bruce Beutler
• MGI ID: MGI:6113401
• Synonyms: glacier
• Gene: Pax5 Location: Chr4:44524757-44710487 bp, - strand Genetic Position: Chr4, 23.55 cM
• Alliance: Pax5^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 44,679,494 (v38) on chromosome 4, or base pair 30,947 in the GenBank genomic region NC_000070. The mutation corresponds to residue 582 in the mRNA sequence NM_008782 within exon 5 of 10 total exons and to residue 284 in the cDNA sequence ENSMUST00000186542.1 within exon 3 of 3 total exons. The mutated nucleotide is indicated in red. The mutation results in a histidine (H) to leucine (L) substitution at position 95 (H95L) in the protein encoded by the ENSMUST00000186542.1 cDNA transcript and a isoleucine (I) to phenylalanine substitution at position 184 in the protein encoded by the NM_008782 mRNA transcript. (J:254824)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax5 Mutation: 35 strains or lines available

References

• Original: J:254824 Zhong X, et al., Mutagenetix entry for glacier. MGI Direct Data Submission. 2018
• All: 1 reference(s)