Met Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Met
met proto-oncogene
MGI:96969

78 phenotypes from 12 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Gt(ROSA)26Sor^{tm1(Actb-Met)Fmai}/? \Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	normal vision/eye phenotype	J:173661
\Met^Par4/\Met⁺ involves: BALB/cJ * SWR/J	decreased lung tumor incidence	J:43176
\Met^tm1.1Sst/\Met^tm1.1Sst involves: 129P2/OlaHsd * C57BL/6	abnormal liver development	J:89236
	prenatal lethality, complete penetrance	J:89236
\Met^tm1Cbm/\Met⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal tongue morphology	J:28570
\Met^tm1Cbm/\Met^tm1Cbm involves: 129P2/OlaHsd	abnormal placenta labyrinth morphology	J:68751
	decreased liver weight	J:68751
	decreased trophoblast giant cell number	J:68751
\Met^tm1Cbm/\Met^tm1Cbm involves: 129P2/OlaHsd * C57BL/6	abnormal diaphragm development	J:28570
	abnormal intrinsic tongue muscle morphology	J:28570
	abnormal liver parenchyma morphology	J:28570
	abnormal muscle precursor cell migration	J:28570
	abnormal myogenesis	J:28570
	abnormal placenta development	J:28570
	decreased fetal size	J:28570
	decreased tongue size	J:28570
	hypaxial muscle hypoplasia	J:28570
	lethality throughout fetal growth and development, complete penetrance	J:28570
	small liver	J:28570
\Met^tm1Cbm/\Met^tm1Cbm involves: ICR	abnormal diaphragm morphology	J:80685
	abnormal muscle precursor cell migration	J:80685
	diaphragmatic hernia	J:80685
	hypaxial muscle hypoplasia	J:80685
	thin diaphragm muscle	J:80685
\Met^tm1Kln/\Met^tm1Kln involves: 129/Sv * C57BL/6 * CD-1	abnormal fetal growth/weight/body size	J:94030
	abnormal liver development	J:94030
	abnormal myoblast migration	J:94030
	abnormal myogenesis	J:94030
	abnormal somatic motor system morphology	J:94030
	decreased liver weight	J:94030
	decreased skeletal muscle mass	J:94030
	dilated liver sinusoidal space	J:94030
	lethality throughout fetal growth and development, complete penetrance	J:94030
	small placenta	J:94030
\Met^tm1Sst/\Met^tm1Sst involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:89236
\Met^tm1Sst/\Met^tm1Sst \Sftpc^{tm1(cre/ERT2,rtTA)Hap}/\Sftpc⁺ involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal pulmonary alveolus morphology	J:264185
	emphysema	J:264185
	overexpanded pulmonary alveolus	J:264185
\Met^tm1Sst/\Met^tm1Sst \Speer6-ps1^{Tg(Alb-cre)21Mgn}/\Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal hepatocyte physiology	J:89236
	abnormal response to injury	J:89236
	abnormal susceptibility to injury induced morbidity/mortality	J:89236
	impaired liver regeneration	J:89236
	impaired wound healing	J:89236
	increased hepatocyte apoptosis	J:89236
	liver failure	J:89236
	liver hemorrhage	J:89236
\Met^tm1Sst/\Met^tm1Sst \Tg(mI56i-cre,-EGFP)1Kc/0 involves: 129P2/OlaHsd * C57BL/6J * FVB	abnormal brain interneuron morphology	J:170554
	abnormal learning/memory/conditioning	J:170554
	abnormal orbitofrontal cortex morphology	J:170554
	abnormal primary somatosensory cortex morphology	J:170554
	abnormal striatum morphology	J:170554
	normal behavior/neurological phenotype	J:170554
	impaired cued conditioning behavior	J:170554
\Met^tm1Sst/\Met^tm1Sst \Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	abnormal cerebral cortex morphology	J:351261
	impaired contextual conditioning behavior	J:351261
\Met^tm1Sst/\Met^tm1Sst \Tg(Pdx1-cre)89.1Dam/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal pancreatic beta cell physiology	J:196854
	abnormal pancreatic islet morphology	J:196854
	decreased circulating insulin level	J:196854
	decreased insulin secretion	J:196854
	decreased pancreatic beta cell mass	J:196854
	decreased pancreatic beta cell proliferation	J:196854
	impaired glucose tolerance	J:196854
	increased circulating glucose level	J:196854
\Met^tm1Sst/\Met^tm1Sst \Tg(SFTPC-rtTA)5Jaw/0 \Tg(tetO-cre)1Jaw/0 involves: 129 * 129P2/OlaHsd * C57BL/6	abnormal lung development	J:124125
	abnormal lung saccule morphology	J:124125
\Met^tm2Cbm/\Met^tm2.1Cbm \Tg(Mx1-cre)1Cgn/? involves: C57BL/6 * CBA	impaired liver regeneration	J:91484
	microvesicular hepatic steatosis	J:91484
\Met^tm2Kln/\Met^tm2Kln involves: 129/Sv * C57BL/6 * CD-1	abnormal diaphragm morphology	J:94030
	abnormal fetal growth/weight/body size	J:94030
	abnormal liver development	J:94030
	abnormal motor neuron innervation pattern	J:94030
	abnormal myoblast migration	J:94030
	abnormal myogenesis	J:94030
	abnormal somatic motor system morphology	J:94030
	decreased liver weight	J:94030
	decreased skeletal muscle mass	J:94030
	dilated liver sinusoidal space	J:94030
	normal embryo phenotype	J:94030
	neonatal lethality, complete penetrance	J:94030
	respiratory failure	J:94030
\Met^tm3Kln/\Met^tm3Kln involves: 129/Sv * C57BL/6 * CD-1	no abnormal phenotype detected	J:94030
\Met^tm4Gvw/\Met⁺ involves: 129 * C57BL/6J	chromosome breakage	J:94722
	glomerulonephritis	J:94722
	hydronephrosis	J:94722
	increased lymphoma incidence	J:94722
	increased sarcoma incidence	J:94722
	increased tumor incidence	J:94722
\Met^tm4Gvw/\Met⁺ involves: 129 * C57BL/6J * FVB/N	increased hemangiosarcoma incidence	J:151890
	increased mammary adenocarcinoma incidence	J:151890
	increased mammary gland tumor incidence	J:151890
	increased myoepithelioma incidence	J:151890
	increased sarcoma incidence	J:151890
	increased squamous cell carcinoma incidence	J:151890
\Met^tm4Gvw/\Met^tm4Gvw involves: 129 * C57BL/6J	embryonic lethality during organogenesis, complete penetrance	J:94722
\Met^tm5Gvw/\Met⁺ involves: 129 * C57BL/6J	normal mortality/aging	J:94722
\Met^tm5Gvw/\Met⁺ involves: 129 * C57BL/6J	normal neoplasm	J:94722

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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