100 phenotypes from 10 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Itgb2em1(IMPC)Bay/Itgb2em1(IMPC)Bay C57BL/6N-Itgb2em1(IMPC)Bay/BayMmucd	decreased prepulse inhibition	J:211773
Itgb2M1Btlr/Itgb2M1Btlr C57BL/6J-Itgb2M1Btlr	abnormal NK cell differentiation	J:139559
	decreased interferon-gamma secretion	J:139559
	normal immune system phenotype	J:139559
Itgb2m2Btlr/Itgb2m2Btlr C57BL/6J-Itgb2m2Btlr	increased interferon-beta secretion	J:265125
Itgb2m3Btlr/Itgb2m3Btlr C57BL/6J-Itgb2m3Btlr	abnormal cytotoxic T cell cytolysis	J:265126
	decreased B cell number	J:265126
	decreased CD4-positive, alpha-beta T cell number	J:265126
	decreased CD8-positive, alpha-beta T cell number	J:265126
	decreased dendritic cell number	J:265126
	decreased IgG level	J:265126
	decreased macrophage cell number	J:265126
	decreased neutrophil cell number	J:265126
	decreased single-positive T cell number	J:265126
	impaired humoral immune response	J:265126
	impaired natural killer cell mediated cytotoxicity	J:265126
	increased dendritic cell number	J:265126
	increased effector memory CD4-positive, alpha-beta T cell number	J:265126
	increased IgE level	J:265126
	increased NK T cell number	J:265126
Itgb2M4Btlr/Itgb2M4Btlr C57BL/6J-Itgb2M4Btlr	abnormal T cell differentiation	J:272843
	increased effector memory CD4-positive, alpha-beta T cell number	J:272843
Itgb2m5Btlr/Itgb2m5Btlr C57BL/6J-Itgb2m5Btlr	increased B-1b cell number	J:272844
Itgb2tm1.1Arte/Itgb2tm1.1Arte involves: C57BL/6NTac	abnormal T cell physiology	J:202261
	decreased T cell proliferation	J:202261
	enlarged spleen	J:202261
	increased B cell number	J:202261
	increased dendritic cell number	J:202261
	increased neutrophil cell number	J:202261
	increased T cell number	J:202261
	lymph node hypoplasia	J:202261
Itgb2tm1.1Mskim/Itgb2tm1.1Mskim B6.129S6-Itgb2tm1.1Mskim	no abnormal phenotype detected	J:184820
Itgb2tm1Bay/Itgb2tm1Bay B6.129S7-Itgb2tm1Bay/J	abnormal eye physiology	J:118466
	abnormal retina morphology	J:118466, J:119416
	abnormal retina vasculature morphology	J:118466
	decreased susceptibility to induced choroidal neovascularization	J:119416
	increased circulating glucose level	J:118466
	premature death	J:118466
Itgb2tm1Bay/Itgb2tm1Bay involves: 129S7/SvEvBrd	decreased inflammatory response	J:13599
	increased granulocyte number	J:13599
	increased leukocyte cell number	J:13599, J:32126
	increased lymphocyte cell number	J:13599
	normal integument phenotype	J:32126
Itgb2tm1Bay/Itgb2tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal spleen red pulp morphology	J:13599
	normal integument phenotype	J:32126
	myeloid hyperplasia	J:13599
Itgb2tm1Bay/Itgb2tm1Bay involves: 129S7/SvEvBrd * C57BL/6J * PL/J	alopecia	J:84126
	dermatitis	J:84126
	normal integument phenotype	J:32126, J:84126
	psoriasis	J:84126
	reddish skin	J:84126
Itgb2tm1Bay/Itgb2tm1Bay involves: 129S7/SvEvBrd * PL/J	abnormal cytokine level	J:109598
	abnormal dermal layer morphology	J:32126
	abnormal epidermal layer morphology	J:32126
	abnormal hair follicle dermal papilla morphology	J:32126
	abnormal skin condition	J:32126
	abnormal spleen morphology	J:32126
	abnormal T cell activation	J:109598
	alopecia	J:32126, J:109598
	dermatitis	J:32126, J:109598
	enlarged lymph nodes	J:32126
	epidermal hyperplasia	J:32126
	increased basophil cell number	J:32126
	increased eosinophil cell number	J:32126
	increased interferon-gamma secretion	J:109598
	increased leukocyte cell number	J:32126
	increased lymphocyte cell number	J:32126
	increased monocyte cell number	J:32126
	increased neutrophil cell number	J:32126
	increased T cell number	J:109598
	increased T-helper 1 cell number	J:109598
	normal integument phenotype	J:32126
	mixed cellular infiltration to dermis	J:32126
	myeloid hyperplasia	J:32126
	orthokeratosis	J:32126
	parakeratosis	J:32126
	normal pigmentation phenotype	J:32126
	psoriasis	J:32126, J:109598
	reddish skin	J:32126
	scaly skin	J:32126, J:109598
	thrombocytosis	J:32126
Itgb2tm1Bay/Itgb2tm2Bay B6.129S7-Itgb2tm1Bay Itgb2tm2Bay	normal integument phenotype	J:84126
Itgb2tm1Bay/Itgb2tm2Bay involves: 129S7/SvEvBrd * C57BL/6J * PL/J	abnormal skin condition	J:84126
	acanthosis	J:84126
	dermatitis	J:84126
	hyperkeratosis	J:84126
	psoriasis	J:84126
Itgb2tm1Bay/Itgb2tm2Bay PL.129S7-Itgb2tm1Bay Itgb2tm2Bay	abnormal skin condition	J:84126
	acanthosis	J:84126
	dermatitis	J:84126
	orthokeratosis	J:84126
	parakeratosis	J:84126
	psoriasis	J:84126
Itgb2tm2Bay/Itgb2tm2Bay B6.129S7-Itgb2tm2Bay	abnormal bone structure	J:101407
	abnormal leukocyte adhesion	J:83226
	abnormal leukocyte migration	J:83226
	abnormal long bone metaphysis morphology	J:101407
	decreased bone mineral density of femur	J:101407
	decreased bone mineralization	J:101407
	decreased bone ossification	J:101407
	decreased susceptibility to bacterial infection	J:94855
	decreased trabecular bone mass	J:101407
	increased eosinophil cell number	J:83226
	increased leukocyte cell number	J:83226
	increased lymphocyte cell number	J:83226
	increased monocyte cell number	J:83226
	increased neutrophil cell number	J:83226
	osteoporosis	J:101407
Itgb2tm2Bay/Itgb2tm2Bay involves: 129S7/SvEvBrd	decreased T cell proliferation	J:90954
Itgb2tm2Bay/Itgb2tm2Bay involves: 129S7/SvEvBrd * C57BL/6	decreased acute inflammation	J:112286
	impaired neutrophil recruitment	J:112286
	increased neutrophil cell number	J:112286
	spontaneous skin ulceration	J:112286
Itgb2tm2Bay/Itgb2tm2Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal immune system cell morphology	J:48542
	abnormal leukocyte physiology	J:48542
	abnormal lymph organ size	J:48542
	abnormal neutrophil morphology	J:48542
	abnormal neutrophil physiology	J:48542
	abnormal T cell proliferation	J:48542
	alopecia	J:48542
	conjunctivitis	J:48542
	dermatitis	J:48542
	enlarged lymph nodes	J:48542
	enlarged spleen	J:48542
	epidermal hyperplasia	J:48542
	increased bone marrow cell number	J:48542
	increased circulating interleukin-3 level	J:48542
	increased circulating interleukin-6 level	J:48542
	increased IgA level	J:48542
	increased IgG level	J:48542
	increased IgM level	J:48542
	increased immunoglobulin level	J:48542
	increased inflammatory response	J:48542
	increased leukocyte cell number	J:48542
	increased lymphocyte cell number	J:48542
	increased monocyte cell number	J:48542
	increased neutrophil cell number	J:48542
	increased susceptibility to bacterial infection	J:48542
	myeloid hyperplasia	J:48542
	perinatal lethality, incomplete penetrance	J:48542
	reddish skin	J:48542
Itgb2tm2Bay/Itgb2tm2Bay involves: 129S7/SvEvBrd * PL/J	normal integument phenotype	J:84126
Itgb2tm2Bay/Itgb2tm2Bay PL.129S7-Itgb2tm2Bay	decreased susceptibility to type IV hypersensitivity reaction	J:109598
	normal integument phenotype	J:109598