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Itgb2tm2Bay
Targeted Allele Detail
Summary
Symbol: Itgb2tm2Bay
Name: integrin beta 2; targeted mutation 2, Baylor College of Medicine
MGI ID: MGI:1861705
Synonyms: beta2-, CD18-, CD18 null, Itgb2-
Gene: Itgb2  Location: Chr10:77366164-77401542 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Itgb2tm2Bay page
Skeletal abnormalities in Itgb2tm2Bay/Itgb2tm2Bay mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:13599
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette disrupted the 5' boundary of exon 3. No protein was synthesized from this allele. (J:48542)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Itgb2 Mutation:  36 strains or lines available
References
Original:  J:13599 Wilson RW, et al., Gene targeting yields a CD18-mutant mouse for study of inflammation. J Immunol. 1993 Aug 1;151(3):1571-8
All:  118 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory