Itgb2^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Itgb2^tm1.1Arte
• Name: integrin beta 2; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5524988
• Synonyms: beta2^TTT/AAA
• Gene: Itgb2 Location: Chr10:77366164-77401542 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Itgb2^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202261
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 16 was replaced with a modified one in which nucleotide substitutions result in the amino acid substitution of alanine for threonine at positions 759, 760 and 761 (T759A, T760A, T761A). These mutations abolish Fermt3 (Kindlin 3) binding but did not affect talin binding. Flp-mediated recombination removed the F3-flanked puromycin resistance cassette inserted upstream of exon 15. (J:202261)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb2 Mutation: 49 strains or lines available

References

• Original: J:202261 Morrison VL, et al., The beta2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo. Blood. 2013 Aug 22;122(8):1428-36
• All: 4 reference(s)