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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Hgf
hepatocyte growth factor
MGI:96079
29 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Cd44tm1Mak/\Cd44tm1Mak
\Hgftm1Kita/\Hgf+
involves: 129S4/SvJae * C57BL/6 		neonatal lethality, incomplete penetrance J:128984
\Cdk4tm1.1Bbd/\Cdk4+
\Tg(Mt1-Hgf)#Lmb/0
B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb 		abnormal axillary lymph node morphology J:111992
abnormal inguinal lymph node morphology J:111992
decreased tumor growth/size J:111992
enlarged axillary lymph nodes J:111992
enlarged inguinal lymph nodes J:111992
increased incidence of tumors by chemical induction J:111992
increased metastatic potential J:111992
\Cdk4tm1.1Bbd/\Cdk4tm1.1Bbd
\Krt14tm1(cre)Wbm/\Krt14+
\Pard3tm1Shoh/\Pard3tm1Shoh
\Tg(Mt1-Hgf)#Lmb/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J 		increased incidence of tumors by chemical induction J:240961
increased metastatic potential J:240961
increased tumor growth/size J:240961
\Cdk4tm1.1Bbd/\Cdk4tm1.1Bbd
\Tg(Mt1-Hgf)#Lmb/0
B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb 		abnormal axillary lymph node morphology J:111992
abnormal inguinal lymph node morphology J:111992
enlarged axillary lymph nodes J:111992
enlarged inguinal lymph nodes J:111992
increased cutaneous melanoma incidence J:111992
increased incidence of tumors by chemical induction J:111992
increased metastatic potential J:111992
increased skin nevi incidence J:111992
increased tumor growth/size J:111992
\Cdkn2atm1Cjs/\Cdkn2a+
\Tg(CKMM-tTA)A3Rhvh/0
\Tg(tetO-Hgf,-EGFP)24Tcre/0
involves: 129X1/SvJ * FVB 		increased rhabdomyosarcoma incidence J:237183
\Cdkn2atm1Cjs/\Cdkn2atm1Cjs
\Pax7tm1Pgr/\Pax7+
\Tg(CKMM-tTA)A3Rhvh/0
\Tg(tetO-Hgf,-EGFP)24Tcre/0
involves: 129S2/SvPas * 129X1/SvJ * FVB 		increased rhabdomyosarcoma incidence J:237183
increased sarcoma incidence J:237183
\Cdkn2atm1Cjs/\Cdkn2atm1Cjs
\Pax7tm1Pgr/\Pax7tm1Pgr
\Tg(CKMM-tTA)A3Rhvh/0
\Tg(tetO-Hgf,-EGFP)24Tcre/0
involves: 129S2/SvPas * 129X1/SvJ * FVB 		increased rhabdomyosarcoma incidence J:237183
increased sarcoma incidence J:237183
\Cdkn2atm1Cjs/\Cdkn2atm1Cjs
\Tg(CKMM-tTA)A3Rhvh/0
\Tg(tetO-Hgf,-EGFP)24Tcre/0
involves: 129X1/SvJ * FVB 		increased rhabdomyosarcoma incidence J:237183
skeletal muscle hyperplasia J:237183
\Cdkn2atm1Rdp/\Cdkn2atm1Rdp
\Tg(Mt1-Hgf)19Lmb/0
involves: 129/Sv * C57BL/6J * FVB/N * SJL 		abnormal myogenesis J:79704
increased melanoma incidence J:79704
increased rhabdomyosarcoma incidence J:79704
increased satellite cell number J:79704
increased tumor incidence J:79704
\Ctnnb1tm1Mmt/\Ctnnb1+
\Tg(Wap-cre)11738Mam/0
\Tg(Wap-Hgf)402Mig/0
FVB.Cg-Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig 		abnormal mammary gland growth during lactation J:206839
abnormal mammary gland morphology J:206839
increased mammary gland tumor incidence in breeding females J:206839
increased mammary gland tumor incidence in virgin females J:206839
mammary gland alveolar hyperplasia J:206839
\Ctnnb1tm1Mmt/\Ctnnb1+
\Cxcr4tm2Yzo/\Cxcr4tm2Yzo
\Tg(Wap-cre)11738Mam/0
\Tg(Wap-Hgf)402Mig/0
FVB.Cg-Cxcr4tm2Yzo Ctnnb1tm1Mmt Tg(Wap-cre)11738Mam Tg(Wap-Hgf)402Mig 		decreased mammary gland tumor incidence in breeding females J:206839
\Hgftm1Jmw/\Hgftm1Jmw
\Rag2tm1Fwa/\Rag2tm1Fwa
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased hepatocyte proliferation J:97145
impaired liver regeneration J:97145
\Tg(Dct-Birc5)21Gros/0
\Tg(Mt1-Hgf)19Lmb/0
involves: C57BL/6 * CBA * FVB/N 		decreased cellular sensitivity to ultraviolet irradiation J:122181
increased incidence of tumors by UV-induction J:122181
increased melanoma incidence J:122181
increased metastatic potential J:122181
increased skin tumor incidence J:122181
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory