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Hgf Gene Detail
Summary
  • Symbol
    Hgf
  • Name
    hepatocyte growth factor
  • Synonyms
    C230052L06Rik, HGF/SF, NK1, NK2, scatter factor, SF/HGF
  • Feature Type
    protein coding gene
  • IDs
    MGI:96079
    NCBI Gene: 15234
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:16758493-16825150 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 7.07 cM, cytoband A2-A3
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    549 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96079
protein coding gene Chr5:16758493-16827448 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029299
protein coding gene Chr5:13922386-13992524 (+)
A/J MGP_AJ_G0029263
protein coding gene Chr5:13484887-13551374 (+)
AKR/J MGP_AKRJ_G0029213
protein coding gene Chr5:14111018-14177595 (+)
BALB/cJ MGP_BALBcJ_G0029279
protein coding gene Chr5:13922640-13988930 (+)
C3H/HeJ MGP_C3HHeJ_G0029000
protein coding gene Chr5:14084465-14154518 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029731
protein coding gene Chr5:15178008-15249275 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026973
protein coding gene Chr5:11840023-11909452 (+)
CAST/EiJ MGP_CASTEiJ_G0028412
protein coding gene Chr5:13388562-13463763 (+)
CBA/J MGP_CBAJ_G0028962
protein coding gene Chr5:15098324-15174944 (+)
DBA/2J MGP_DBA2J_G0029115
protein coding gene Chr5:13784422-13851172 (+)
FVB/NJ MGP_FVBNJ_G0029077
protein coding gene Chr5:13214597-13281550 (+)
LP/J MGP_LPJ_G0029203
protein coding gene Chr5:14348856-14420181 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029105
protein coding gene Chr5:16084219-16162642 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029763
protein coding gene Chr5:13711987-13790307 (+)
PWK/PhJ MGP_PWKPhJ_G0028134
protein coding gene Chr5:12854860-12921223 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027967
protein coding gene Chr5:13061155-13133528 (+)
WSB/EiJ MGP_WSBEiJ_G0028492
protein coding gene Chr5:13733597-13804944 (+)



Homology
more
  • Human Ortholog
    HGF, hepatocyte growth factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HGF, hepatocyte growth factor
  • Synonyms
    DFNB39, F-TCF, HGFB, HPTA, SF
  • Links
    NCBI Gene ID: 3082
    neXtProt AC: NX_P14210
    UniProt: P14210

  • Chr Location
    7q21.11; chr7:81699010-81770438 (-)  GRCh38

Human Diseases
more
  • Diseases
    2 with Hgf mouse models; 16 with human HGF associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    66 phenotypes from 12 alleles in 16 genetic backgrounds
    28 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028864 Ensembl Gene Model | MGI Sequence Detail 66658 C57BL/6J ±  kb
    transcript ENSMUST00000030683 Ensembl | MGI Sequence Detail 2642 Not Applicable  
    polypeptide ENSMUSP00000030683 Ensembl | MGI Sequence Detail 728 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 10
      cDNA 40
      Primer pair 19
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10704, MGI:2443459
    References
    more
    • Summaries
      All 279
      Developmental Gene Expression 77
      Diseases 6
      Gene Ontology 15
      Phenotypes 72
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:339972 Filliol A, et al., Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis. Nature. 2022 Oct;610(7931):356-365

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/12/2024
    MGI 6.13
    The Jackson Laboratory