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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Hgf
hepatocyte growth factor
MGI:96079
66 phenotypes from 12 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Cdk4+/Cdk4+
Tg(Mt1-Hgf)#Lmb/0
B6.Cg-Cdk4tm1.1Bbd Tg(Mt1-Hgf)#Lmb
abnormal axillary lymph node morphology J:111992
abnormal inguinal lymph node morphology J:111992
increased incidence of tumors by chemical induction J:111992
increased metastatic potential J:111992
increased skin tumor incidence J:111992
Hgftm1.1Tbf/Hgftm1.1Tbf
B6.Cg-Hgftm1.1Tbf/Tbf
abnormal strial intermediate cell morphology J:289982
decreased endocochlear potential J:289982
impaired hearing J:289982
thin stria vascularis J:289982
Hgftm1Cbm/Hgf+
involves: 129P2/OlaHsd * C57BL/6
small liver J:23170
Hgftm1Cbm/Hgftm1Cbm
involves: 129P2/OlaHsd * C57BL/6
abnormal hepatocyte morphology J:23170
abnormal liver morphology J:23170
abnormal placenta morphology J:23170
decreased erythrocyte cell number J:23170
decreased fetal weight J:23170
decreased trophoblast giant cell number J:23170
dilated liver sinusoidal space J:23170
disorganized placental labyrinth J:23170
dissociated hepatocytes J:23170
internal hemorrhage J:23170
irregular heartbeat J:23170
lethality throughout fetal growth and development, complete penetrance J:23170
liver hypoplasia J:23170
small liver J:23170
Hgftm1Jmw/Hgftm1Jmw
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
decreased hepatocyte proliferation J:97145
Hgftm1Jmw/Hgftm1Jmw
Tg(Mx1-cre)29-4Her/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL
decreased hepatocyte proliferation J:97145
impaired liver regeneration J:97145
Hgftm1Jmw/Hgftm1Jmw
Tg(Pax2-cre)1Akg/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
abnormal strial intermediate cell morphology J:289982
Hgftm1Kita/Hgftm1Kita
involves: 129S4/SvJae * C57BL/6
abnormal placental labyrinth vasculature morphology J:23171
decreased embryo size J:23171
decreased trophoblast giant cell number J:23171
lethality throughout fetal growth and development, complete penetrance J:23171
small liver J:23171
small placenta J:23171
Hgftm1Tbf/Hgftm1Tbf
B6.Cg-Hgftm1Tbf/Tbf
abnormal distortion product otoacoustic emission J:289982
abnormal organ of Corti supporting cell morphology J:289982
abnormal stria vascularis morphology J:289982
abnormal strial intermediate cell morphology J:289982
normal behavior/neurological phenotype J:289982
cochlear outer hair cell degeneration J:289982
decreased cochlear outer hair cell number J:289982
decreased endocochlear potential J:289982
impaired hearing J:289982
organ of Corti degeneration J:289982
spiral ligament degeneration J:289982
thin stria vascularis J:289982
Tg(CKMM-tTA)A3Rhvh/0
Tg(tetO-Hgf,-EGFP)24Tcre/0
involves: FVB
abnormal skeletal muscle fiber morphology J:237183
decreased skeletal muscle fiber size J:237183
increased satellite cell number J:237183
Tg(Ggt1-tTA)#Agoc/0
Tg(tetO/CMV-Hgf)#Agoc/0
involves: CD-1
decreased susceptibility to kidney reperfusion injury J:130310
Tg(Hgf)1Paus/0
Not Specified
abnormal hair cycle catagen phase J:65035
increased hair follicle number J:65035
premature hair follicle generation J:65035
thick skin J:65035
Tg(Mt1-Hgf)19Lmb/0
involves: C57BL/6 * CBA * FVB/N
increased skin tumor incidence J:122181
normal neoplasm J:122181
Tg(Mt1-Hgf)19Lmb/0
involves: C57BL/6 * FVB/N
abnormal extracutaneous pigmentation J:34022
abnormal melanoblast migration J:34022
ectopic melanocytes J:34022
ectopic skeletal muscle J:34022
hyperpigmentation J:34022
Tg(Mt1-Hgf)19Lmb/0
involves: FVB/N
abnormal spinal cord ventral horn morphology J:50947
ectopic melanocytes J:50947
ectopic skeletal muscle J:34022
hindlimb paralysis J:34022
increased cutaneous melanoma incidence J:50947
increased melanoma incidence J:50947
increased metastatic potential J:50947
intestinal obstruction J:34022
kidney failure J:34022
premature death J:34022
Tg(Mt1-Hgf)37Lmb/0
involves: C57BL/6 * FVB/N
hyperpigmentation J:34022
Tg(Mt1-Hgf)37Lmb/0
involves: FVB/N
intestinal obstruction J:34022
kidney failure J:34022
premature death J:34022
Tg(Mt1-Hgf)#Lmb/0
B6.FVB-Tg(Mt1-Hgf)#Lmb
hyperpigmentation J:111992
increased ear pigmentation J:111992
increased foot pigmentation J:111992
reduced female fertility J:111992
Tg(Wap-Hgf)402Mig/0
FVB/N-Tg(Wap-Hgf)402Mig
increased mammary adenocarcinoma incidence J:206839
increased mammary gland tumor incidence in breeding females J:206839
Tg(Wap-Hgf)402Mig/0
involves: FVB/N
abnormal branching of the mammary ductal tree J:86776
abnormal mammary gland morphology J:86776
increased mammary adenocarcinoma incidence J:86776
increased mammary gland tumor incidence in breeding females J:86776
increased mammary gland tumor incidence in virgin females J:86776
increased metastatic potential J:86776
mammary gland duct hyperplasia J:86776

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory