Grin2d Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Grin2d
glutamate receptor, ionotropic, NMDA2D (epsilon 4)
MGI:95823

31 phenotypes from 3 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ Grin2d^em10Frk/Grin2d⁺ (B6.Cg-Edil3^{Tg(Sox2-cre)1Amc}/J x C57BL/6J-Grin2d^em10Frk/FrkJ)F1	abnormal long-term potentiation	J:372150
	abnormal nervous system electrophysiology	J:372150
	abnormal postsynaptic density morphology	J:372150
	abnormal spike wave discharge	J:372150
	abnormal synaptic bouton morphology	J:372150
	absence seizures	J:372150
	cerebellum hypoplasia	J:372150
	decreased body weight	J:372150
	decreased locomotor activity	J:372150
	decreased striatum size	J:372150
	decreased survivor rate	J:372150
	enhanced long-term potentiation	J:372150
	excessive vocalization	J:372150
	hypothalamus hypoplasia	J:372150
	impaired coordination	J:372150
	impaired spatial learning	J:372150
	limb grasping	J:372150
	prolonged excitatory postsynaptic current decay time	J:372150
	sudden unexpected death in epilepsy	J:372150
	thalamus hypoplasia	J:372150
Grin2d^em10Frk/Grin2d^em10Frk C57BL/6J-Grin2d^em10Frk/FrkJ	no abnormal phenotype detected	J:372150
Grin2d^{tm1a(EUCOMM)Wtsi}/Grin2d^{tm1a(EUCOMM)Wtsi} Not Specified	abnormal bone mineralization	J:165965
	abnormal bone structure	J:165965
	decreased body weight	J:165965
	decreased circulating sodium level	J:165965
	decreased circulating triglyceride level	J:165965
	decreased heart weight	J:165965
	decreased lean body mass	J:165965
Grin2d^tm1Mim/Grin2d^tm1Mim B6.Cg-Grin2d^tm1Mim	increased startle reflex	J:89405
Grin2d^tm1Mim/Grin2d^tm1Mim involves: C57BL/6 * CBA	normal behavior/neurological phenotype	J:28825
	decreased locomotor activity	J:28825
	decreased vertical activity	J:28825
	normal nervous system phenotype	J:28825

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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