Grin2d^tm1Mim
Targeted Allele Detail

Summary

• Symbol: Grin2d^tm1Mim
• Name: glutamate receptor, ionotropic, NMDA2D (epsilon 4); targeted mutation 1, Masayoshi Mishina
• MGI ID: MGI:1928298
• Synonyms: GluR epsilon4
• Gene: Grin2d Location: Chr7:45481307-45520708 bp, - strand Genetic Position: Chr7, 29.54 cM
• Alliance: Grin2d^tm1Mim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:28825
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The exon encoding the M4 putative transmembrane segment was interrupted by the insertion of a neomycin cassette. (J:28825)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grin2d Mutation: 34 strains or lines available

References

• Original: J:28825 Ikeda K, et al., Reduced spontaneous activity of mice defective in the epsilon 4 subunit of the NMDA receptor channel. Brain Res Mol Brain Res. 1995 Oct;33(1):61-71
• All: 26 reference(s)