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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Fyn
Fyn proto-oncogene
MGI:95602
46 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background
Annotated Term Reference
Blktm1Tara/Blktm1Tara
Fyntm1Sor/Fyntm1Sor
Lyntm1Ard/Lyntm1Ard
either: B6.129-Lyntm1Ard Fyntm1Sor Blktm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)
abnormal B cell differentiation J:115080
abnormal pro-B cell differentiation J:115080
arrested B cell differentiation J:115080
decreased B cell number J:115080
decreased immature B cell number J:115080
decreased pre-B cell number J:115080
Fyntm1Rmp/Fyntm1Rmp
Lcktm1Mak/Lcktm1Mak
involves: 129S2/SvPas
abnormal alpha-beta intraepithelial T cell morphology J:112977
abnormal NK T cell number J:37940
absent CD4-positive, alpha-beta T cells J:37940
absent CD8-positive, alpha-beta T cells J:37940
absent T cells J:37062
arrested T cell differentiation J:37062, J:37940
decreased double-positive T cell number J:37940
decreased gamma-delta intraepithelial T cell number J:37940, J:112977
thymus hypoplasia J:37062, J:37940
Fyntm1Sor/Fyntm1Sor
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129S7/SvEvBrd * 129X1/SvJ
abnormal regulatory T cell physiology J:152472
decreased regulatory T cell number J:152472
decreased T cell proliferation J:152472
enlarged lymph nodes J:152472
increased regulatory T cell number J:152472
increased T cell number J:152472
Fyntm1Sor/Fyntm1Sor
Srctm1Sor/Src+
involves: 129S7/SvEvBrd
abnormal nursing J:20346
reduced female fertility J:20346
Fyntm1Sor/Fyntm1Sor
Srctm1Sor/Srctm1Sor
involves: 129S7/SvEvBrd
decreased body size J:20346
decreased body weight J:20346
postnatal lethality, complete penetrance J:20346
Fyntm1Sor/Fyntm1Sor
Yes1tm1Sor/Yes1tm1Sor
involves: 129S7/SvEvBrd
abnormal dentate gyrus morphology J:20346
abnormal hippocampus morphology J:20346
abnormal kidney morphology J:20346
abnormal renal glomerulus morphology J:20346
abnormal renal tubule morphology J:20346
cortical renal glomerulopathies J:20346
decreased body size J:20346
enlarged spleen J:20346
extramedullary hematopoiesis J:20346
glomerulosclerosis J:20346
increased spleen white pulp amount J:20346
increased urine protein level J:20346
myeloid hyperplasia J:20346
postnatal lethality, incomplete penetrance J:20346
ruffled hair J:20346
small kidney J:20346
weight loss J:20346
Fyntm1Yik/Fyntm1Yik
Ptk2tm1Lfr/Ptk2+
involves: 129X1/SvJ * C57BL/6 * CBA
abnormal T cell differentiation J:110771
decreased double-positive T cell number J:110771
decreased thymocyte number J:110771
thymus cortex atrophy J:110771
Lcktm1Mak/Lcktm1Mak
Rag1tm1Mom/Rag1+
Tg(Lck-Fyn*Y528F)5525Cjg/0
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
abnormal T cell differentiation J:37062
decreased T cell number J:37062

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory