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Fyn Gene Detail
Summary
  • Symbol
    Fyn
  • Name
    Fyn proto-oncogene, Src family tyrosine kinase
  • Synonyms
    Src Kinase p59
  • Feature Type
    protein coding gene
  • IDs
    MGI:95602
    NCBI Gene: 14360
  • Alliance
    genome feature page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39245735-39441377 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 20.51 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5933 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95602
 protein coding gene Chr10:39244851-39441377 (+)
129S1/SvImJ ENSMUSG00200008830
 protein coding gene Chr10:36100057-36296579 (+)
A/J ENSMUSG00195015456
 protein coding gene Chr10:36402675-36599226 (+)
AKR/J ENSMUSG00220025523
 protein coding gene Chr10:36079346-36275895 (+)
BALB/cJ ENSMUSG00180015450
 protein coding gene Chr10:36487969-36684505 (+)
C3H/HeJ ENSMUSG00175011052
 protein coding gene Chr10:36282326-36478887 (+)
C57BL/6NJ ENSMUSG00215007721
 protein coding gene Chr10:36032850-36229386 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015246
 protein coding gene Chr10:34858834-35053021 (+)
CAST/EiJ ENSTCUG00005026160
 protein coding gene Chr10:36484124-36683892 (+)
CBA/J ENSMUSG00210025428
 protein coding gene Chr10:36175812-36372352 (+)
DBA/2J ENSMUSG00185006837
 protein coding gene Chr10:36328358-36524928 (+)
FVB/NJ ENSMUSG00205011751
 protein coding gene Chr10:36242941-36439499 (+)
JF1/MsJ ENSUMUG00000019767
 protein coding gene Chr10:36085628-36289930 (+)
LP/J ENSMUSG00230013458
 protein coding gene Chr10:38089113-38285637 (+)
NOD/ShiLtJ ENSMUSG00190028020
 protein coding gene Chr10:36456709-36653249 (+)
NZO/HlLtJ ENSMUSG00225015877
 protein coding gene Chr10:42415964-42612495 (+)
PWK/PhJ ENSLUMG00010007524
 protein coding gene Chr10:36212325-36410889 (+)
SPRET/EiJ ENSMSPG00010018151
 protein coding gene Chr10:37390048-37444192 (+)
WSB/EiJ ENSIUOG00005014007
 protein coding gene Chr10:35992821-36193026 (+)



Homology
more
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
  • Synonyms
    p59-FYN, SLK, SYN
  • Links
    NCBI Gene ID: 2534
    UniProt: P06241

  • Chr Location
    6q21; chr6:111660332-111873475 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fyn mouse models; 4 with human FYN associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    111 phenotypes from 10 alleles in 14 genetic backgrounds
    46 phenotypes from multigenic genotypes
    274 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    227
  • GO References
    65
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    219
  • cDNA Data
    25
  • Literature Summary
    48
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14360 NCBI Gene Model | MGI Sequence Detail 195643 C57BL/6J ±  kb
    transcript NM_001122893 RefSeq | MGI Sequence Detail 3549 C57BL/6  
    polypeptide P39688 UniProt | EBI | MGI Sequence Detail 537 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 3
      cDNA 30
      Primer pair 5
      Other 3
      Antibodies 9

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9909, MGI:2143602, MGI:2143864
    References
    more
    • Summaries
      All 596
      Developmental Gene Expression 48
      Diseases 2
      Gene Ontology 65
      Phenotypes 274
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:383105 Kuprasertkul N, et al., Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression. J Clin Invest. 2026 Apr 15;136(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory