Fyn^tm1Yik
Targeted Allele Detail

Summary

• Symbol: Fyn^tm1Yik
• Name: Fyn proto-oncogene; targeted mutation 1, Yoji Ikawa
• MGI ID: MGI:1930480
• Synonyms: fyn-, fyn^z
• Gene: Fyn Location: Chr10:39245735-39441377 bp, + strand Genetic Position: Chr10, 20.51 cM
• Alliance: Fyn^tm1Yik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:16461
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Replacement of the SH2, SH3 and tyrosine kinase regions of the gene with lacZ. A fusion protein consisiting of the unique region of the protein and beta-galactosidase is expressed from this allele. (J:16461)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	44 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fyn Mutation: 37 strains or lines available

References

• Original: J:16461 Yagi T, et al., A role for Fyn tyrosine kinase in the suckling behaviour of neonatal mice. Nature. 1993 Dec 23-30;366(6457):742-5
• All: 45 reference(s)