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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cdh1
cadherin 1
MGI:88354
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Apctm1Rak/\Apc+
\Cdh1tm1Cbm/\Cdh1+
involves: 129P2/OlaHsd * C57BL/6J 		increased intestinal adenocarcinoma incidence J:65142
increased stomach tumor incidence J:65142
\Cdh1tm1.1Mpst/\Cdh1tm2Kem
\Gt(ROSA)26Sortm1Sor/\Gt(ROSA)26Sor+
\Tg(Vil1-cre)20Syr/0
involves: 129 * C57BL/6 * DBA/2 		no abnormal phenotype detected J:163273
\Cdh1tm1Jjon/\Cdh1+
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		increased mammary adenocarcinoma incidence J:116152
increased pilomatricoma incidence J:116152
increased skin tumor incidence J:116152
increased squamous cell carcinoma incidence J:116152
\Cdh1tm1Jjon/\Cdh1+
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Wap-cre)51Nki/0
involves: 129P2/OlaHsd * FVB/N 		increased mammary adenocarcinoma incidence J:171765
increased mammary gland tumor incidence J:171765
\Cdh1tm1Jjon/\Cdh1tm1Jjon
\Trp53tm1Brn/\Trp53+
\Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		abnormal tumor vascularization J:116152
increased mammary adenocarcinoma incidence J:116152
increased metastatic potential J:116152
increased skin tumor incidence J:116152
\Cdh1tm1Jjon/\Cdh1tm1Jjon
\Trp53tm1Brn/\Trp53+
\Tg(Wap-cre)51Nki/0
involves: 129P2/OlaHsd * FVB/N 		hypolactation J:171765
increased mammary gland tumor incidence J:171765
increased metastatic potential J:171765
\Cdh1tm1Jjon/\Cdh1tm1Jjon
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		abnormal tumor vascularization J:116152
increased mammary adenocarcinoma incidence J:116152
increased metastatic potential J:116152
increased skin tumor incidence J:116152
\Cdh1tm1Jjon/\Cdh1tm1Jjon
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Wap-cre)51Nki/0
involves: 129P2/OlaHsd * FVB/N 		abnormal mammary gland duct morphology J:171765
abnormal mammary gland growth during pregnancy J:171765
abnormal mammary gland lobule morphology J:171765
increased mammary gland tumor incidence J:171765
increased metastatic potential J:171765
lactation failure J:171765
\Cdh1tm2.1Mpst/\Cdh1tm2.1Mpst
involves: C57BL/6 * FVB/N 		absent blastocoele J:183847
absent trophectoderm J:183847
increased trophectoderm apoptosis J:183847
\Cdh1tm2Kem/\Cdh1+
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		normal neoplasm J:212549
\Cdh1tm2Kem/\Cdh1+
\Smad4tm2.1Cxd/\Smad4tm2.1Cxd
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(MMTV-cre)7Mul/0
involves: 129 * C57BL/6 * FVB/N 		increased mammary adenocarcinoma incidence J:212549
increased metastatic potential J:212549
\Cdh1tm2Kem/\Cdh1+
\Smad4tm2.1Cxd/\Smad4tm2.1Cxd
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Pdx1-cre)6Tuv/0
involves: 129 * C57BL/6 * FVB/N 		increased duodenum adenocarcinoma incidence J:212549
increased gastric adenocarcinoma incidence J:212549
increased metastatic potential J:212549
increased squamous cell carcinoma incidence J:212549
premature death J:212549
\Cdh1tm2Kem/\Cdh1+
\Smad4tm2.1Cxd/\Smad4tm2.1Cxd
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Vil1-cre)20Syr/0
involves: 129 * C57BL/6 * DBA/2 		increased intestinal adenocarcinoma incidence J:212549
\Cdh1tm2Kem/\Cdh1tm2Kem
\Smad4tm2.1Cxd/\Smad4tm2.1Cxd
\Trp53tm1Brn/\Trp53tm1Brn
\Tg(Pdx1-cre)6Tuv/0
involves: 129 * C57BL/6 * FVB/N 		increased gastric adenocarcinoma incidence J:212549
\Cdh1tm2Kem/\Cdh1tm2Kem
\Tg(KRT14-cre)1Efu/0
\Tg(Krt14-RNAi:Cdh3)1Efu/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal epidermal layer morphology J:144091
abnormal epidermis stratum basale morphology J:144091
abnormal epidermis stratum spinosum morphology J:144091
abnormal epidermis suprabasal layer morphology J:144091
abnormal skin condition J:144091
abnormal skin physiology J:144091
blistering J:144091
decreased birth body size J:144091
decreased hair follicle number J:144091
flaky skin J:144091
impaired skin barrier function J:144091
neonatal lethality, complete penetrance J:144091
shiny skin J:144091
thick epidermis J:144091
tight skin J:144091
\Cdh1tm3.1Mpst/\Cdh1tm3.1Mpst
involves: C57BL/6 * FVB/N 		abnormal trophectoderm morphology J:183847
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory