Cdh1^tm1Cbm
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm1Cbm
• Name: cadherin 1; targeted mutation 1, Carmen Birchmeier
• MGI ID: MGI:2182564
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm1Cbm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22631
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 7 and all of exon 8 were replaced with a neomycin selection cassette, which introducecd stop codons into all three reading frames. The deleted region encoded an essential calcium-binding domain. Low levels of residual protein were detected in homozygous mutant embryos during early stages of development via immunohistological analysis. (J:22631)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 171 strains or lines available

References

• Original: J:22631 Riethmacher D, et al., A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):855-9
• All: 3 reference(s)