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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Bcl3
B cell leukemia/lymphoma 3
MGI:88140
74 phenotypes from 9 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Bcl3m1Btlr/Bcl3+
C57BL/6J-Bcl3m1Btlr
decreased B cell number J:255184
decreased B-1b cell number J:255184
increased CD8-positive, alpha-beta T cell number J:255184
increased macrophage cell number J:255184
Bcl3m1Btlr/Bcl3m1Btlr
C57BL/6J-Bcl3m1Btlr
abnormal humoral immune response J:255184
decreased B cell number J:255184
decreased B-1b cell number J:255184
decreased IgE level J:255184
decreased IgG level J:255184
increased B-1 B cell number J:255184
increased CD8-positive, alpha-beta T cell number J:255184
increased central memory CD4-positive, alpha-beta T cell number J:255184
increased macrophage cell number J:255184
Bcl3m2Btlr/Bcl3m2Btlr
C57BL/6J-Bcl3m2Btlr
decreased CD4-positive, alpha-beta T cell number J:264818
decreased IgD level J:264818
increased B-1 B cell number J:264818
increased CD8-positive, alpha-beta memory T cell number J:264818
increased IgM level J:264818
Bcl3m3Btlr/Bcl3m3Btlr
C57BL/6J-Bcl3m3Btlr
decreased central memory CD8 positive, alpha-beta T cell number J:274858
Bcl3tm1b(EUCOMM)Wtsi/Bcl3tm1b(EUCOMM)Wtsi
C57BL/6N-Bcl3tm1b(EUCOMM)Wtsi/H
abnormal snout morphology J:211773
increased spleen weight J:211773
thrombocytopenia J:211773
Bcl3tm1Rie/Bcl3tm1Rie
involves: 129
abnormal dendritic cell number J:77049
abnormal follicular dendritic cell morphology J:77049
abnormal myeloid dendritic cell morphology J:77049
abnormal Peyer's patch follicle morphology J:77049
abnormal Peyer's patch germinal center morphology J:77049
abnormal Peyer's patch morphology J:77049
abnormal Peyer's patch T cell area morphology J:77049
decreased B cell number J:77049
decreased Peyer's patch number J:77049
increased plasmacytoid dendritic cell number J:77049
small Peyer's patches J:77049
Bcl3tm1Rsch/Bcl3tm1Rsch
B6.Cg-Bcl3tm1Rsch
abnormal cytokine secretion J:116724
abnormal enzyme/coenzyme activity J:116724
abnormal macrophage physiology J:116724
Bcl3tm1Rsch/Bcl3tm1Rsch
involves: 129P2/OlaHsd * CD-1
abnormal cytokine secretion J:116724
abnormal innate immunity J:116724
increased susceptibility to bacterial infection J:116724
Bcl3tm1Sbn/Bcl3tm1Sbn
involves: 129S4/SvJae
abnormal B cell physiology J:207111
decreased B cell proliferation J:207111
decreased follicular B cell number J:207111
decreased transitional stage T1 B cell number J:207111
decreased transitional stage T2 B cell number J:207111
increased B cell proliferation J:207111
increased marginal zone B cell number J:207111
Bcl3tm1Sbn/Bcl3tm1Sbn
involves: 129S4/SvJae * C57BL/6
abnormal B cell differentiation J:39747
abnormal class switch recombination J:39747
abnormal cytotoxic T cell physiology J:39747
abnormal lymph node B cell domain morphology J:39747
abnormal lymphocyte morphology J:39747
abnormal metallophilic macrophage morphology J:39747
abnormal nitric oxide homeostasis J:39747
abnormal spleen marginal zone macrophage morphology J:39747
absent spleen germinal center J:39747
decreased B cell number J:39747
decreased IgG2a level J:39747
decreased interferon-gamma secretion J:39747
decreased interleukin-12 secretion J:39747
decreased macrophage cell number J:39747
decreased spleen germinal center size J:39747
disorganized spleen B cell follicle J:39747
increased susceptibility to induced morbidity/mortality J:39747
increased susceptibility to parasitic infection J:39747
intermingled spleen red and white pulp J:39747
lymph node hypoplasia J:39747
Bcl3tm1Ver/Bcl3tm1Ver
involves: 129P2/OlaHsd * FVB/NJ
abnormal humoral immune response J:38092
absent spleen germinal center J:38092
normal immune system phenotype J:38092
increased susceptibility to bacterial infection J:38092
Gt(ROSA)26Sortm1(CAG-Bcl3,-EGFP)Hoev/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd
abnormal B cell differentiation J:208980
abnormal B-2 B cell morphology J:208980
abnormal class switch recombination J:208980
abnormal follicular B cell morphology J:208980
abnormal Peyer's patch germinal center morphology J:208980
abnormal transitional stage T3 B cell morphology J:208980
absent marginal zone B cells J:208980
decreased B cell apoptosis J:208980
decreased B cell proliferation J:208980
decreased B-1 B cell number J:208980
decreased B-1a cell number J:208980
decreased IgG1 level J:208980
decreased IgG2b level J:208980
decreased IgG3 level J:208980
decreased IgM level J:208980
decreased immature B cell number J:208980
decreased marginal zone B cell number J:208980
decreased transitional stage T1 B cell number J:208980
enlarged spleen J:208980
increased lymphocyte cell number J:208980

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory