Bcl3^tm1Sbn
Targeted Allele Detail

Summary

• Symbol: Bcl3^tm1Sbn
• Name: B cell leukemia/lymphoma 3; targeted mutation 1, Ulrich Siebenlist
• MGI ID: MGI:2158443
• Synonyms: Bcl3^-
• Gene: Bcl3 Location: Chr7:19542387-19556691 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Bcl3^tm1Sbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39747
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing the coding sequences for most of the ankyrin repeat-encoding exons was replaced with a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues of homozygous mice demonstrated that no detectable transcript was produced from this allele. (J:39747)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl3 Mutation: 56 strains or lines available

References

• Original: J:39747 Franzoso G, et al., Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions. Immunity. 1997 Apr;6(4):479-90
• All: 16 reference(s)