Bcl3^em1Dvs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bcl3^em1Dvs
• Name: B cell leukemia/lymphoma 3; endonuclease-mediated mutation 1, David V Serreze
• MGI ID: MGI:8257378
• Synonyms: Bcl3-
• Gene: Bcl3 Location: Chr7:19542387-19556691 bp, - strand Genetic Position: Chr7, 9.95 cM
• Alliance: Bcl3^em1Dvs page

Mutation origin

• Strain of Origin: NOD/ShiLtDvs

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/cas9-mediated excision of all of exons 3-7 yielded this 3287 bp dropout mutation (J:373825)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl3 Mutation: 57 strains or lines available

References

• Original: J:373825 Racine JJ, et al., Direct-in-NOD genetic ablation of Bcl3 leads to complete type 1 diabetes protection. J Immunol. 2025
• All: 1 reference(s)