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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl3em1Dvs
endonuclease-mediated mutation 1, David V Serreze
MGI:8257378
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bcl3em1Dvs/Bcl3em1Dvs NOD/ShiLtDvs-Bcl3em1Dvs/Dvs MGI:8257381


Genotype
MGI:8257381
hm1
Allelic
Composition		 Bcl3em1Dvs/Bcl3em1Dvs
Genetic
Background		 NOD/ShiLtDvs-Bcl3em1Dvs/Dvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl3em1Dvs mutation (0 available); any Bcl3 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:373825 )
• Homozygotes have reduced insulitis and are completely protected from developing type I diabetes even at 30 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory