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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Agtr1a
angiotensin II receptor, type 1a
MGI:87964
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Agtr1atm1Afu/\Agtr1atm1Afu
\Agtr2tm1Gsb/Y
mixed 		abnormal systemic arterial blood pressure J:107851
increased fluid intake J:107851
\Agtr1atm1Tma/\Agtr1atm1Tma
\Agtr1btm1Ii/\Agtr1btm1Ii
involves: 129P2/OlaHsd * C57BL/6 		abnormal kidney development J:46007
abnormal kidney papilla morphology J:46007
abnormal kidney vasculature morphology J:46007, J:112003
abnormal systemic arterial blood pressure J:46007
absent kidney pelvis J:112003
decreased heart weight J:46007
decreased systemic arterial blood pressure J:46007
dilated kidney calyx J:46007
kidney papillary hypoplasia J:46007
muscular ventricular septal defect J:46007
perimembraneous ventricular septal defect J:46007
postnatal lethality, incomplete penetrance J:46007
ventricular septal defect J:46007
\Agtr1atm1Uky/\Agtr1atm1Uky
\Ldlrtm1Her/\Ldlrtm1Her
\Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6N * SJL 		normal cardiovascular system phenotype J:170230
\Agtr1atm1Uky/\Agtr1atm1Uky
\Ldlrtm1Her/\Ldlrtm1Her
\Tg(Tek-cre)12Flv/0
involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6N 		abnormal aorta elastic fiber morphology J:170230
abnormal ascending aorta morphology J:170230
decreased aorta wall thickness J:170230
decreased susceptibility to induced aneurysm formation J:170230
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr1btm1Cof/\Agtr1btm1Cof
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating protein level J:137944
abnormal kidney vasculature morphology J:137944
abnormal physiological response to xenobiotic J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased body weight J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased kidney weight J:137944
decreased mean systemic arterial blood pressure J:137944
dilated renal tubule J:137944
increased glomerular capsule space J:137944
kidney cyst J:137944
kidney inflammation J:137944
postnatal lethality, incomplete penetrance J:137944
renal glomerulus atrophy J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr1btm1Cof/\Agtr1btm1Cof
\Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal heart rate J:137944
abnormal physiological response to xenobiotic J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased body weight J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased kidney weight J:137944
decreased mean systemic arterial blood pressure J:137944
hydronephrosis J:137944
postnatal lethality, incomplete penetrance J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr1btm1Cof/\Agtr1btm1Cof
\Agtr2tm1Tin/\Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 		abnormal heart rate J:137944
abnormal physiological response to xenobiotic J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased body weight J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased kidney weight J:137944
decreased mean systemic arterial blood pressure J:137944
hydronephrosis J:137944
postnatal lethality, incomplete penetrance J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr1btm1Cof/\Agtr1btm1Cof
\Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		decreased renin activity J:91837
kidney cyst J:91837
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr2tm1Tin/Y
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating protein level J:137944
abnormal heart rate J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased kidney weight J:137944
decreased mean systemic arterial blood pressure J:137944
increased glomerular capsule space J:137944
renal glomerulus atrophy J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
\Agtr2tm1Tin/\Agtr2tm1Tin
involves: 129P2/OlaHsd * C57BL/6 		abnormal circulating protein level J:137944
abnormal heart rate J:137944
abnormal response/metabolism to endogenous compounds J:137944
abnormal systemic arterial blood pressure J:137944
decreased heart rate J:137944
decreased heart weight J:137944
decreased kidney weight J:137944
decreased mean systemic arterial blood pressure J:137944
increased glomerular capsule space J:137944
renal glomerulus atrophy J:137944
\Agtr1atm1Unc/\Agtr1atm1Unc
\Efemp2tm1.1Hiya/\Efemp2tm1.2Hiya
\Tg(Tagln-cre)1Her/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL 		increased aorta wall thickness J:213282
\Agtr1atm1Unc/\Agtr1atm1Unc
\Hprt1tm1(Ggt1-Agtr1)Cof/Y
involves: 129P2/OlaHsd 		decreased urine osmolality J:91837
hypotension J:91837
\Agtr1atm1Unc/\Agtr1atm1Unc
\Ldlrtm1Her/\Ldlrtm1Her
B6.129-Ldlrtm1Her Agtr1atm1Unc 		decreased susceptibility to induced aneurysm formation J:170230
\Agtr1atm3Tma/\Agtr1atm3Tma
\Tg(Nphs1-cre)10Mska/0
\Tg(Nphs1-IL2RA)18Mska/0
involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA/2 		normal renal/urinary system phenotype J:240316
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory