51 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac Insrtm1Dac/Insrtm1Dac involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	increased circulating ketone body level	J:91350
	postnatal lethality, complete penetrance	J:91350
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac Insrtm1Dac/Insrtm1Dac Tg(Camk2a-cre)#Szi/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac Insrtm1Dac/Insrtm1Dac Tg(Hsp70-1-cre)6Arge/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac Insrtm1Dac/Insrtm1Dac Tg(Nes-cre)1Kln/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * SJL	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actbtm1(INSR)Dac/Actbtm1(INSR)Dac Insrtm1Dac/Insrtm1Dac Tg(Syn1-cre)671Jxm/? involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA	increased circulating glucose level	J:91350
	increased circulating insulin level	J:91350
	premature death	J:91350
Actbtm1(PyVT)Arge/Actb+ involves: 129S1/Sv	increased hemangioma incidence	J:87544
	increased mammary adenocarcinoma incidence	J:87544
	premature death	J:87544
Actbtm1(PyVT)Arge/Actb+ Waptm1(cre)Arge/Wap+ involves: 129S1/Sv	decreased cardiac muscle contractility	J:87544
	increased mammary adenocarcinoma incidence	J:87544
	premature death	J:87544
Actbtm1(PyVT)Arge/Actb+ Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	embryonic lethality between implantation and somite formation, complete penetrance	J:87544
Actbtm1.1(tetO-COP4*/EYFP)Kftnk/Actb+ Tg(Mlc1-tTA)2Rhn/0 involves: 129 * 129S4/SvJaeSor * C57BL/6 * CBA	abnormal astrocyte physiology	J:193127
	abnormal neuron physiology	J:193127
Actbtm1.1Erv/Actbtm1.1Erv Actg1tm1.2Erv/Actg1tm1.2Erv Tg(Atoh1-cre)1Bfri/? involves: 129/Sv * C57BL/6 * CBA * FVB/N	abnormal cochlear hair cell stereociliary bundle morphology	J:167543
Actbtm2(Tag)Arge/Actb+ involves: 129S1/Sv	increased sarcoma incidence	J:87544
Actbtm2(Tag)Arge/Actb+ Tg(Hsp70-1-cre)1Arge/0 involves: 129S1/Sv * C57BL/6J * CBA	abnormal smooth muscle morphology	J:87544
	abnormal uterus morphology	J:87544
	enlarged gallbladder	J:87544
	enlarged seminal vesicle	J:87544
	increased leiomyosarcoma incidence	J:87544
Actbtm3.1(Sirt1)Npa/Actb+ involves: 129/Sv * C57BL/6 * C57BL/6J	abnormal motor coordination/balance	J:160212
	normal behavior/neurological phenotype	J:160212
	decreased body weight	J:160212
	decreased circulating adiponectin level	J:160212
	decreased circulating cholesterol level	J:160212
	decreased circulating free fatty acids level	J:160212
	decreased circulating HDL cholesterol level	J:160212
	decreased circulating insulin level	J:160212
	decreased circulating LDL cholesterol level	J:160212
	decreased circulating leptin level	J:160212
	decreased epididymal fat pad weight	J:160212
	decreased fasting circulating glucose level	J:160212
	delayed fertility	J:160212
	normal homeostasis/metabolism phenotype	J:160212
	improved glucose tolerance	J:160212
	increased food intake	J:160212
	increased oxygen consumption	J:160212
	preweaning lethality, incomplete penetrance	J:160212
Actbtm3.1(Sirt1)Npa/Actb+ Sirt1tm1Mcby/Sirt1tm1Mcby involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	normal growth/size/body region phenotype	J:160212
	normal reproductive system phenotype	J:160212
	normal vision/eye phenotype	J:160212
Actbtm3.1(Sirt1)Npa/Actbtm3.1(Sirt1)Npa involves: 129/Sv * C57BL/6 * C57BL/6J	preweaning lethality, complete penetrance	J:160212
Actbtm4(cre/ERT2)Npa/Actb+ Sgpl1tm1.1Npa/Sgpl1tm1.1Npa involves: BALB/cJ * C57BL/6	abnormal lipid homeostasis	J:199525
	abnormal lymph node morphology	J:199525
	abnormal regulatory T cell number	J:199525
	abnormal type IV hypersensitivity reaction	J:199525
	decreased follicular B cell number	J:199525
	decreased marginal zone B cell number	J:199525
	decreased single-positive T cell number	J:199525
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:199525
	normal growth/size/body region phenotype	J:199525
	increased thymocyte number	J:199525
	normal mortality/aging	J:199525
	spleen hypoplasia	J:199525