Actb^tm1.1Erv
Targeted Allele Detail

Summary

• Symbol: Actb^tm1.1Erv
• Name: actin, beta; targeted mutation 1.1, James M Ervasti
• MGI ID: MGI:4881824
• Synonyms: Actb^flox
• Gene: Actb Location: Chr5:142888870-142892509 bp, - strand Genetic Position: Chr5, 81.8 cM
• Alliance: Actb^tm1.1Erv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167543
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed PGK-neomycin selection cassette in reverse orientation was inserted in intron 1 and a third loxP site was placed in intron 3. The selection cassette was subsequently removed from properly targeted mice by crossing to transgenic mice carrying Tg(EIIa-cre)C5379Lmgd. (J:167543)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Actb Mutation: 51 strains or lines available

References

• Original: J:167543 Perrin BJ, et al., beta-actin and gamma-actin are each dispensable for auditory hair cell development but required for Stereocilia maintenance. PLoS Genet. 2010;6(10):e1001158
• All: 10 reference(s)