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Allele Symbol Allele Name Allele ID |
Actbtm1.1Erv targeted mutation 1.1, James M Ervasti MGI:4881824 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hair cells lack stereocilia at 5 days of age
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• hair cells lack stereocilia at 5 days of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice seldom survive to adulthood
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| N |
• stereocilia are apparently normal at 2 days of age
• stereocilia are still present at 21 days of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• stereocilia develop normally to 2 days of age
• stereocilia are still present at 10 days of age
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• stereocilia loss at 18 weeks of age is modest with apical and middle regions of the cochlea more or less normal
• middle region sterocilia become abnormal by 24 weeks of age
• more stereocilia are retained but they become shorter
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• basal region stereocilia are shortened at 18 weeks of age
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• in 6 week old mice, ABR is normal between 4 and 16 kHz, shows a slightly elevated threshold at 22 kHz and a markedly elevated threshold at 32 kHz
• at 18 weeks, a moderate elevation in ABR threshold is seen at 11 and 16 kHz with a more severe elevation in threshold at 22 and 32 kHZ
• further elevation in ABR thresholds at all frequencies at 24 weeks with elevated thresholds at lower frequencies as well
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• hearing losses preferentially at higher frequencies
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• stereocilia loss at 18 weeks of age is modest with apical and middle regions of the cochlea more or less normal
• middle region sterocilia become abnormal by 24 weeks of age
• more stereocilia are retained but they become shorter
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• basal region stereocilia are shortened at 18 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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