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Actb Gene Detail
Summary
  • Symbol
    Actb
  • Name
    actin, beta
  • Synonyms
    Actx, A-X actin-like protein, beta-actin, E430023M04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87904
    NCBI Gene: 11461
  • Alliance
    gene page
  • Transcription Start Sites
    36 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142888870-142892509 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.80 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87904
 protein coding gene Chr5:142888870-142892509 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030319
 protein coding gene Chr5:148201911-148206756 (-)
A/J MGP_AJ_G0030288
 protein coding gene Chr5:141836298-141840735 (-)
AKR/J MGP_AKRJ_G0030220
 protein coding gene Chr5:146253009-146258524 (-)
BALB/cJ MGP_BALBcJ_G0030305
 protein coding gene Chr5:143084577-143088440 (-)
C3H/HeJ MGP_C3HHeJ_G0030016
 protein coding gene Chr5:147082924-147087599 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030750
 protein coding gene Chr5:153599831-153604861 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027968
 protein coding gene Chr5:135639099-135642017 (-)
CAST/EiJ MGP_CASTEiJ_G0029421
 protein coding gene Chr5:146562083-146566901 (-)
CBA/J MGP_CBAJ_G0029986
 protein coding gene Chr5:159897681-159901160 (-)
DBA/2J MGP_DBA2J_G0030136
 protein coding gene Chr5:141599791-141603266 (-)
FVB/NJ MGP_FVBNJ_G0030091
 protein coding gene Chr5:140804682-140808488 (-)
LP/J MGP_LPJ_G0030222
 protein coding gene Chr5:148798403-148803076 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030122
 protein coding gene Chr5:162378436-162383291 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030790
 protein coding gene Chr5:146113139-146117769 (-)
PWK/PhJ MGP_PWKPhJ_G0029136
 protein coding gene Chr5:140684107-140687901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028972
 protein coding gene Chr5:143872357-143875284 (-)
WSB/EiJ MGP_WSBEiJ_G0029495
 protein coding gene Chr5:146911571-146916412 (-)



Homology
more
  • Human Ortholog
    ACTB, actin beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTB, actin beta
  • Synonyms
    BKRNS, BNS, BRWS1, CSMH, DDS1, PS1TP5BP1, THC8
  • Links
    NCBI Gene ID: 60
    neXtProt AC: NX_P60709
    UniProt: P60709

  • Chr Location
    7p22.1; chr7:5526409-5563902 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ACTB associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 9 alleles in 10 genetic backgrounds
    51 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are embryonic lethal. Homozygotes for a hypomorphic targeted mutation develop normally until embryonic day 8.5; are growth retarded by day 9.5 and die shortly thereafter.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    143
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    63
  • cDNA Data
    90
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11461 NCBI Gene Model | MGI Sequence Detail 3640 C57BL/6J ±  kb
    transcript NM_007393 RefSeq | MGI Sequence Detail 1935 Not Specified  
    polypeptide P60710 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 4
      cDNA 91
      Primer pair 17
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1087, MGD-MRK-1096, MGI:2443247, MGI:87910
    References
    more
    • Summaries
      All 382
      Developmental Gene Expression 87
      Gene Ontology 48
      Phenotypes 128
    • Earliest
      J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
    • Latest
      J:345940 Miyazaki Y, et al., Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Rep. 2024 Jan 23;43(1):113634
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory