Actb^{tm4(cre/ERT2)Npa}
Targeted Allele Detail

Summary

• Symbol: Actb^{tm4(cre/ERT2)Npa}
• Name: actin, beta; targeted mutation 4, Novartis Pharma AG
• MGI ID: MGI:5514361
• Gene: Actb Location: Chr5:142888870-142892509 bp, - strand Genetic Position: Chr5, 81.8 cM
• Alliance: Actb^{tm4(cre/ERT2)Npa} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199525
• Parent Cell Line: BALB/c-I (ES Cell)
• Strain of Origin: BALB/cJ

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Actb^{tm4(cre/ERT2)Npa} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Actb (MGI:87904)

• Mutation details: Cre recombinase fused to the modified estrogen receptor sequence (ERT2) was inserted into the Actin beta gene by homologous recombination. (J:129105, J:199525)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Actb (mouse) Summary of all recombinase alleles driven by Actb. Alliance mouse Actb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Actb Mutation: 51 strains or lines available

References

• Original: J:199525 Billich A, et al., Partial deficiency of sphingosine-1-phosphate lyase confers protection in experimental autoimmune encephalomyelitis. PLoS One. 2013;8(3):e59630
• All: 4 reference(s)