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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Lin28b
lin-28 homolog B
MGI:3584032
47 phenotypes from 9 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Gt(ROSA)26Sortm2(CAG-Lin28b,-luc)Jhsc/Gt(ROSA)26Sor+
Tg(Dbh-icre)1Gsc/0
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6
increased neuroblastoma incidence J:241988
Lin28btm1.1Gqda/Lin28btm1.1Gqda
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
decreased body size J:199720
Lin28btm1.2Gqda/Lin28btm1.2Gqda
STOCK Lin28btm1.2Gqda/J
no abnormal phenotype detected J:101977
Lin28btm1b(EUCOMM)Hmgu/Lin28btm1b(EUCOMM)Hmgu
C57BL/6N-Lin28btm1b(EUCOMM)Hmgu/J
decreased exploration in new environment J:211773
Lin28btm1Gqda/Lin28btm1.1Gqda
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6
decreased body size J:199720
normal growth/size/body region phenotype J:199720
Lin28btm1Gqda/Lin28btm1Gqda
Myf5tm1(cre)Mrc/Myf5+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
decreased body size J:199720
impaired glucose tolerance J:199720
insulin resistance J:199720
normal muscle phenotype J:199720
Tg(Vav1-Lin28b)C3Apla/0
involves: C57BL/6
abnormal cytokine level J:189197
abnormal inflammatory response J:189197
abnormal T cell differentiation J:189197
abnormal thymus cell ratio J:189197
abnormal thymus cortex morphology J:189197
abnormal thymus corticomedullary boundary morphology J:189197
anemia J:189197
ascites J:189197
decreased CD4-positive, alpha-beta T cell number J:189197
decreased CD8-positive, alpha-beta T cell number J:189197
decreased double-positive T cell number J:189197
decreased leukocyte cell number J:189197
decreased lymphocyte cell number J:189197
decreased thymocyte number J:189197
enlarged lymph nodes J:189197
enlarged spleen J:189197
enlarged thymus medulla J:189197
hunched posture J:189197
increased CD8-positive, alpha-beta T cell number J:189197
increased effector memory CD4-positive, alpha-beta T cell number J:189197
increased effector memory CD8-positive, alpha-beta T cell number J:189197
increased eosinophil cell number J:189197
increased IgG level J:189197
increased neutrophil cell number J:189197
increased T cell derived lymphoma incidence J:189197
increased T cell proliferation J:189197
lethargy J:189197
pleural effusion J:189197
premature death J:189197
ruffled hair J:189197
Tg(Vil1-Lin28b,-tdTomato)HiAru/0
involves: C57BL/6J * SJL
abnormal intestinal goblet cell morphology J:202923
abnormal jejunum crypts of Lieberkuhn morphology J:202923
decreased Paneth cell number J:202923
increased intestinal adenoma incidence J:202923
increased small intestine adenocarcinoma incidence J:202923
Tg(Vil1-Lin28b,-tdTomato)LoAru/0
involves: C57BL/6J * SJL
abnormal intestinal mucosa morphology J:202923
abnormal small intestine morphology J:202923
decreased Paneth cell number J:202923
normal digestive/alimentary phenotype J:202923
Tg(Vil1-Lin28b,-tdTomato)MedAru/0
involves: C57BL/6J * SJL
abnormal intestinal mucosa morphology J:202923
abnormal small intestine crypts of Lieberkuhn morphology J:202923
abnormal small intestine morphology J:202923
decreased Paneth cell number J:202923
increased intestinal adenoma incidence J:202923
increased small intestine adenocarcinoma incidence J:202923

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory