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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pofut1
protein O-fucosyltransferase 1
MGI:2153207
48 phenotypes from 5 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mesp1tm2(cre)Ysa/Mesp1+
Pofut1tm1Ysa/Pofut1tm1Ysa
involves: C57BL/6 * CBA * SJL 		abnormal atrioventricular cushion morphology J:139209
abnormal cardiac epithelial to mesenchymal transition J:139209
abnormal heart development J:139209
embryonic lethality during organogenesis J:139209
myocardial trabeculae hypoplasia J:139209
Nanos3tm2.1(cre)Ysa/Nanos3+
Pofut1tm1Ysa/Pofut1tm1.1Ysa
involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj 		normal reproductive system phenotype J:183324
Pofut1cax/Pofut1cax
C3H/HeJ-Pofut1cax/J 		abnormal dorsal-ventral polarity of the somites J:145608
abnormal somite development J:145608
abnormal somite size J:145608
abnormal vertebral column morphology J:145608
absent vertebral spinous process J:145608
decreased body length J:145608
normal embryo phenotype J:145608
hemivertebra J:145608
kinked tail J:145608
rib fusion J:145608
short tail J:145608
small vertebrae J:145608
Pofut1cax/Pofut1cax
involves: C57BL/6J * CAST/Ei 		abnormal vertebral column morphology J:145608
decreased body length J:145608
kinked tail J:145608
short tail J:145608
Pofut1tm1.1Ysa/Pofut1tm1.1Ysa
involves: C57BL/6 * CBA * SJL 		abnormal blood vessel morphology J:139209
abnormal cardiac epithelial to mesenchymal transition J:139209
abnormal heart development J:139209
abnormal heart morphology J:139209
abnormal neural tube morphology J:139209
abnormal somite development J:139209
embryonic growth retardation J:139209
embryonic lethality during organogenesis, complete penetrance J:139209
Pofut1tm1Pst/Pofut1cax
involves: 129/Sv * C57BL/6J * SJL/J 		abnormal dorsal-ventral polarity of the somites J:145608
Pofut1tm1Pst/Pofut1tm1Pst
involves: 129/Sv * C57BL/6 * SJL 		abnormal heart development J:83299
abnormal somite shape J:83299
abnormal somite size J:83299
abnormal vasculogenesis J:83299
absent intersomitic vessels J:83299
absent vitelline blood vessels J:83299
distended pericardium J:83299
embryonic growth retardation J:83299, J:112097
embryonic lethality during organogenesis, complete penetrance J:112097
failure of heart looping J:83299
fused somites J:83299
heart hypoplasia J:83299
kinked neural tube J:83299
Pofut1tm1Ysa/Pofut1tm1.1Ysa
Tg(Amh-cre)#Ysa/0
involves: C3H/HeNJcl * C57BL/6NCrlj * C57BL/6NJcl * CBA/JNCrlj 		prenatal lethality J:183324
normal reproductive system phenotype J:183324
Pofut1tm2Pst/Pofut1tm1Pst
involves: 129/Sv * C57BL/6J * SJL 		abnormal heart development J:102175
abnormal somite shape J:102175
abnormal vasculogenesis J:102175
abnormal vitelline vasculature morphology J:102175
decreased embryo size J:102175
fused somites J:102175
kinked neural tube J:102175
Pofut1tm2Pst/Pofut1tm1Pst
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL 		abnormal bronchiole epithelium morphology J:150051
abnormal respiratory epithelium morphology J:150051
absent club cells J:150051
decreased birth body size J:150051
decreased body size J:150051
increased solitary pulmonary neuroendocrine cell number J:150051
lung inflammation J:150051
postnatal lethality, incomplete penetrance J:150051
premature death J:150051
normal respiratory system phenotype J:150051
Pofut1tm2Pst/Pofut1tm2Pst
Tg(MMTV-cre)1Mam/0
involves: 129P2/OlaHsd * FVB 		abnormal mammary gland growth during pregnancy J:108712
epidermal cyst J:108712
hyperkeratosis J:108712
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory