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Transgenic Allele Detail
Symbol: Plekha5Tg(AMH-cre)1Flor
Name: pleckstrin homology domain containing, family A member 5; transgene insertion 1, Florian Guillou
MGI ID: MGI:2450300
Synonyms: AMH-Cre, Mis-Cre, Tg(AMH-cre)1Flor
Gene: Plekha5  Location: Chr6:140369780-140542836 bp, + strand  Genetic Position: Chr6, 70.34 cM
Alliance: Plekha5Tg(AMH-cre)1Flor page
Loss of germ cells in adult Cyp26b1tm1Ptk/Cyp26b1tm1Ptk Plekha5Tg(AMH-cre)1Flor/0 animals

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  (C57BL/6 x SJL)F1
Transgene Type:    Transgenic (No functional change, Recombinase)
Mutation:    Insertion
Plekha5Tg(AMH-cre)1Flor expression driven by 1 gene
Mutation detailsThe transgene consists of a human AMH promoter, a cre recombinase gene, and genomic sequences from MT1 to provide mRNA secondary structure stability. The gene trap inserted into intron 3. Northern blot analysis shows gonad-specific transgene expression in Sertoli cells of 6 day old male mice and granulosa cells of 16 day old female mice. RT-PCR confirmed normal endogenous gene expression. The insertion site of the original cre transgene was subsequenly identified as intron 3 of Plekha5. (J:81650, J:189585)
 Tissue activity of this recombinase allele
Driver: AMH (human)
Summary of all recombinase alleles driven by AMH.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plekha5 Mutation:  109 strains or lines available
Original:  J:81650 Lecureuil C, et al., Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice. Genesis. 2002 Jul;33(3):114-8
All:  127 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory