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Plekha5Tg(AMH-cre)1Flor
Transgenic Allele Detail
Summary
Symbol: Plekha5Tg(AMH-cre)1Flor
Name: pleckstrin homology domain containing, family A member 5; transgene insertion 1, Florian Guillou
MGI ID: MGI:2450300
Synonyms: AMH-Cre, Mis-Cre, Tg(AMH-cre)1Flor
Gene: Plekha5  Location: Chr6:140369780-140542836 bp, + strand  Genetic Position: Chr6, 70.34 cM
Alliance: Plekha5Tg(AMH-cre)1Flor page
Loss of germ cells in adult Cyp26b1tm1Ptk/Cyp26b1tm1Ptk Plekha5Tg(AMH-cre)1Flor/0 animals

Show the 4 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (No functional change, Recombinase)
Mutation:    Insertion
 
Plekha5Tg(AMH-cre)1Flor expression driven by 1 gene
 
Mutation detailsThe transgene consists of a human AMH promoter, a cre recombinase gene, and genomic sequences from MT1 to provide mRNA secondary structure stability. The gene trap inserted into intron 3. Northern blot analysis shows gonad-specific transgene expression in Sertoli cells of 6 day old male mice and granulosa cells of 16 day old female mice. RT-PCR confirmed normal endogenous gene expression. The insertion site of the original cre transgene was subsequenly identified as intron 3 of Plekha5. (J:81650, J:189585)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: AMH (human)
Summary of all recombinase alleles driven by AMH.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plekha5 Mutation:  109 strains or lines available
References
Original:  J:81650 Lecureuil C, et al., Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice. Genesis. 2002 Jul;33(3):114-8
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory