Pofut1tm1Pst
Targeted Allele Detail
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Symbol: |
Pofut1tm1Pst |
Name: |
protein O-fucosyltransferase 1; targeted mutation 1, Pamela Stanley |
MGI ID: |
MGI:2662305 |
Synonyms: |
Pofut-, Pofut1- |
Gene: |
Pofut1 Location: Chr2:153083453-153112167 bp, + strand Genetic Position: Chr2, 75.41 cM, cytoband H2
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Alliance: |
Pofut1tm1Pst page
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Shortened body axis and defective axial skeleton in Pofut1tm1Pst/Pofut1cax mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:83299
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Parent Cell Line: |
WW6 (ES Cell)
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Strain of Origin: |
STOCK 129/Sv and C57BL/6J and SJL
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: A single loxP site was left in place of exon 2 following homologous recombination and in vitro cre-mediated excision in Pofut1tm2Pst. The deletion of exon 2 putatively results in a nonsense mutation in exon 3. Transcript was undetected in homozygous mutant embyros by whole-mount in situ hybridization.
(J:83299)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pofut1 Mutation: |
22 strains or lines available
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Original: |
J:83299 Shi S, et al., Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5234-9 |
All: |
10 reference(s) |
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