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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pole3
polymerase (DNA directed), epsilon 3 (p17 subunit)
MGI:1933378
26 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pole3em1(IMPC)J/Pole3+
C57BL/6NJ-Pole3em1(IMPC)J/Mmjax 		increased grip strength J:211773
Pole3em1(IMPC)J/Pole3em1(IMPC)J
C57BL/6NJ-Pole3em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Pole3em1Tbo/Pole3em1Tbo
FVB-Pole3em1Tbo 		decreased B cell number J:298827
decreased lymphocyte cell number J:298827
decreased splenocyte number J:298827
decreased thymocyte number J:298827
normal embryo phenotype J:298827
normal mortality/aging J:298827
Pole3em2Tbo/Pole3em2Tbo
FVB-Pole3em2Tbo 		decreased B cell number J:298827
decreased lymphocyte cell number J:298827
decreased splenocyte number J:298827
decreased thymocyte number J:298827
normal embryo phenotype J:298827
normal mortality/aging J:298827
Pole3em3Tbo/Pole3em3Tbo
FVB-Pole3em3Tbo 		abnormal cell cycle J:298827
abnormal thymus apoptosis J:298827
decreased B cell number J:298827
decreased DN4 thymocyte number J:298827
decreased double-positive T cell number J:298827
decreased gamma-delta T cell number J:298827
decreased immature B cell number J:298827
decreased lymphocyte cell number J:298827
decreased pre-B cell number J:298827
decreased splenocyte number J:298827
decreased thymocyte number J:298827
normal embryo phenotype J:298827
increased DN3 thymocyte number J:298827
increased thymocyte apoptosis J:298827
normal mortality/aging J:298827
small spleen J:298827
small thymus J:298827
Pole3em4Tbo/Pole3em4Tbo
FVB-Pole3em4Tbo 		abnormal thymus apoptosis J:298827
decreased B cell number J:298827
decreased DN4 thymocyte number J:298827
decreased immature B cell number J:298827
decreased lymphocyte cell number J:298827
decreased pre-B cell number J:298827
decreased splenocyte number J:298827
decreased thymocyte number J:298827
normal embryo phenotype J:298827
increased DN3 thymocyte number J:298827
increased thymocyte apoptosis J:298827
normal mortality/aging J:298827
preweaning lethality, incomplete penetrance J:298827
Pole3tm1(KOMP)Vlcg/Pole3tm1(KOMP)Vlcg
involves: C57BL/6NTac * FVB 		abnormal brain development J:298827
decreased DN4 thymocyte number J:298827
decreased fetal size J:298827
delayed bone ossification J:298827
increased DN3 thymocyte number J:298827
lethality throughout fetal growth and development, complete penetrance J:298827
short tail J:298827
vertebral fusion J:298827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory