Hic2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hic2
hypermethylated in cancer 2
MGI:1929869

18 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} involves: 129P2/OlaHsd	normal cardiovascular system phenotype	J:225226
Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ involves: 129P2/OlaHsd * C57BL/6J * CBA/J	normal mortality/aging	J:225226
Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Mesp1^tm2(cre)Ysa/Mesp1⁺ involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	atrial septal defect	J:225226
	edema	J:225226
	normal embryo phenotype	J:225226
	hemorrhage	J:225226
	lethality during fetal growth through weaning, incomplete penetrance	J:225226
	overriding aortic valve	J:225226
	prenatal lethality, incomplete penetrance	J:225226
	thin myocardium	J:225226
	ventricular septal defect	J:225226
Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ involves: 129P2/OlaHsd * 129S7/SvEvBrd	embryonic growth retardation	J:225226
	hemorrhage	J:225226
	normal mortality/aging	J:225226
	overriding aortic valve	J:225226
	thin myocardium	J:225226
	ventricular septal defect	J:225226
Hic2^{Gt(E225A08)1.1Wrst}/Hic2^{Gt(E225A08)1.1Wrst} Tg(Mef2c-cre)2Blk/? involves: 129P2/OlaHsd	normal cardiovascular system phenotype	J:225226
	normal mortality/aging	J:225226
Hic2^{Gt(E225A08)1.2Wrst}/Hic2^{Gt(E225A08)1.2Wrst} involves: 129P2/OlaHsd	embryonic lethality, incomplete penetrance	J:225226
Hic2^{Gt(E225A08)Wrst}/Hic2^{Gt(E225A08)Wrst} involves: 129P2/OlaHsd	embryonic lethality, complete penetrance	J:225226
Hic2^{Gt(RRN127)Byg}/Hic2⁺ B6.129P2-Hic2^{Gt(RRN127)Byg}	abnormal myocardial trabeculae morphology	J:225226
	abnormal myocardium layer morphology	J:225226
	muscular ventricular septal defect	J:225226
	overriding aortic valve	J:225226
	prenatal lethality, incomplete penetrance	J:225226
	preweaning lethality	J:225226
	thin myocardium	J:225226
	ventricular septal defect	J:225226
Hic2^{Gt(RRN127)Byg}/Hic2^{Gt(RRN127)Byg} involves: 129P2/OlaHsd * C57BL/6J * CD-1	normal cardiovascular system phenotype	J:225226
	embryonic growth retardation	J:225226
	embryonic lethality, complete penetrance	J:225226

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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