Hic2^{Gt(E225A08)1.2Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Hic2^{Gt(E225A08)1.2Wrst}
• Name: hypermethylated in cancer 2; gene trap E225A08, 1.2, German Gene Trap Consortium
• MGI ID: MGI:5703658
• Gene: Hic2 Location: Chr16:17051451-17081294 bp, + strand Genetic Position: Chr16, 10.68 cM, cytoband B1
• Alliance: Hic2^{Gt(E225A08)1.2Wrst} page

Mutation origin

• Mutant Cell Line: E225A08
• Germline Transmission: Earliest citation of germline transmission: J:225226
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: rsFROSAbgeo+2s
• Mutation details: Hic2^{Gt(E225A08)1.1Wrst} mice were crossed to the ubiquitously expressed ActB-Cre recombinase transgenic line. This re-inverts the genetrap, reactivating the splice acceptor, creating the null allele. (J:225226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hic2 Mutation: 257 strains or lines available

References

• Original: J:225226 Dykes IM, et al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31
• All: 1 reference(s)