121 phenotypes from 3 alleles in 15 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Alpltm1(cre)Nagy/Alpl+ Atg7tm1Tchi/Atg7tm1Tchi involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	abnormal acrosome assembly	J:258511
	abnormal acrosome morphology	J:258511
	abnormal cauda epididymis morphology	J:258511
	abnormal proacrosomal vesicle fusion	J:258511
	abnormal seminiferous tubule morphology	J:258511
	abnormal sperm nucleus morphology	J:258511
	abnormal spermiogenesis	J:258511
	decreased testis weight	J:258511
	globozoospermia	J:258511
	impaired acrosome reaction	J:258511
	impaired autophagy	J:258511
	impaired fertilization	J:258511
	increased male germ cell apoptosis	J:258511
	oligozoospermia	J:258511
	reduced male fertility	J:258511
	small testis	J:258511
Atg7em1(IMPC)Ccpcz/Atg7+ C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz	abnormal heart morphology	J:211773
	abnormal mammary gland morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal skin morphology	J:211773
	enlarged heart	J:211773
	increased circulating serum albumin level	J:211773
	increased circulating total protein level	J:211773
Atg7em1(IMPC)Ccpcz/Atg7em1(IMPC)Ccpcz C57BL/6N-Atg7em1(IMPC)Ccpcz/Ccpcz	abnormal embryo size	J:211773
	no spontaneous movement	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Atg7tm1.1Tchi/Atg7tm1.1Tchi involves: C57BL/6 * CBA * FVB/N	abnormal circulating amino acid level	J:100199
	abnormal intracellular organelle morphology	J:100199
	decreased body weight	J:100199
	neonatal lethality, complete penetrance	J:100199
Atg7tm1Tchi/Atg7tm1Tchi Aviltm2(cre)Fawa/Avil+ involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal sensory neuron morphology	J:160568
	bradykinesia	J:160568
	curly tail	J:160568
	gliosis	J:160568
	increased neuron apoptosis	J:160568
	limb grasping	J:160568
	neurodegeneration	J:160568
	tremors	J:160568
Atg7tm1Tchi/Atg7tm1Tchi Commd10Tg(Vav1-icre)A2Kio/Commd10+ involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj	abnormal common lymphocyte progenitor cell morphology	J:176843
	abnormal hematopoietic stem cell morphology	J:176843
	abnormal hematopoietic stem cell physiology	J:176843
	abnormal leukocyte morphology	J:176843
	decreased B cell number	J:176843
	decreased bone marrow cell number	J:176843
	decreased common myeloid progenitor cell number	J:176843
	decreased hematopoietic stem cell number	J:176843
	decreased leukocyte cell number	J:176843
	decreased NK cell number	J:176843
	decreased T cell number	J:176843
Atg7tm1Tchi/Atg7tm1Tchi En1tm2(cre)Wrst/En1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrlj	abnormal brain morphology	J:192452
	abnormal gait	J:192452
	abnormal locomotor behavior	J:192452
	abnormal neuron morphology	J:192452
	abnormal substantia nigra pars compacta morphology	J:192452
	astrocytosis	J:192452
	ataxia	J:192452
	decreased dopamine level	J:192452
	decreased survivor rate	J:192452
	neuron degeneration	J:192452
	premature death	J:192452
	Purkinje cell degeneration	J:192452
	tremors	J:192452
	weight loss	J:192452
Atg7tm1Tchi/Atg7tm1Tchi Lyz2tm1(cre)Ifo/Lyz2+ involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj	abnormal circulating chemokine level	J:235399
	abnormal kidney morphology	J:235399
	abnormal macrophage physiology	J:235399
	abnormal renal glomerulus morphology	J:235399
	decreased body weight	J:235399
	decreased circulating interleukin-10 level	J:235399
	glomerulonephritis	J:235399
	increased anti-double stranded DNA antibody level	J:235399
	increased anti-nuclear antigen antibody level	J:235399
	increased autoantibody level	J:235399
	increased blood urea nitrogen level	J:235399
	increased circulating creatinine level	J:235399
	increased circulating interleukin-1 beta level	J:235399
	increased circulating interleukin-6 level	J:235399
	increased circulating interleukin-12b level	J:235399
	increased IgG level	J:235399
	increased lymphocyte cell number	J:235399
	increased monocyte cell number	J:235399
	increased neutrophil cell number	J:235399
	increased susceptibility to systemic lupus erythematosus	J:235399
	increased urine protein level	J:235399
Atg7tm1Tchi/Atg7tm1Tchi Slc6a3tm1(cre)Xz/Slc6a3+ involves: 129S1/Sv * C57BL/6NCrlj * CBA/JNCrlj	abnormal neuron morphology	J:192452
	abnormal substantia nigra pars compacta morphology	J:192452
	decreased dopamine level	J:192452
	hyperactivity	J:192452
	neuron degeneration	J:192452
Atg7tm1Tchi/Atg7tm1Tchi Tg(CAG-cre/Esr1*)5Amc/0 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal autophagosome formation	J:258511
Atg7tm1Tchi/Atg7tm1Tchi Tg(Camk2a-cre)T29-1Stl/0 involves: BALB/c * C57BL * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj	abnormal dendritic spine morphology	J:217829
	abnormal response to social novelty	J:217829
	abnormal social investigation	J:217829
	impaired autophagy	J:217829
Atg7tm1Tchi/Atg7tm1Tchi Tg(Mx1-cre)1Cgn/0 involves: C57BL/6 * CBA	abnormal amino acid level	J:100199
	abnormal circulating enzyme level	J:100199
	abnormal hepatocyte mitochondrial morphology	J:100199
	abnormal hepatocyte morphology	J:100199, J:130839
	abnormal liver morphology	J:100199
	abnormal liver physiology	J:100199
	decreased liver function	J:130839
	enlarged liver	J:100199
	impaired autophagy	J:130839
	increased circulating alanine transaminase level	J:100199, J:130839
	increased circulating alkaline phosphatase level	J:100199, J:130839
	increased circulating aspartate transaminase level	J:100199, J:130839
	increased hepatocyte proliferation	J:130839
	increased liver weight	J:100199, J:130839
Atg7tm1Tchi/Atg7tm1Tchi Tg(Nes-cre)1Kln/0 involves: C57BL/6NCrlj * CBA/JNCrlj * SJL	abnormal endoplasmic reticulum morphology	J:298097
	normal cellular phenotype	J:298097
	normal nervous system phenotype	J:298097
Atg7tm1Tchi/Atg7tm1Tchi Tg(Nes-cre)1Wme/0 involves: C57BL/6 * CBA	abnormal nervous system physiology	J:130839
	absent cerebral cortex pyramidal cells	J:130839
	absent hippocampus pyramidal cells	J:130839
	axon degeneration	J:130839
	impaired autophagy	J:130839
	increased neuron apoptosis	J:130839
	limb grasping	J:130839
	tremors	J:130839
Atg7tm1Tchi/Atg7tm1Tchi Tg(SLC18A3-cre)KMisa/0 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	abnormal motor neuron morphology	J:193770
	normal behavior/neurological phenotype	J:193770
Atg7tm1Tchi/Atg7tm1Tchi Tg(Tyr-cre)1Lru/Y involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * DBA/2	abnormal autophagy	J:220623
	abnormal coat/hair pigmentation	J:220623
	abnormal epidermal melanocyte morphology	J:220623
	abnormal epidermal pigmentation	J:220623
	abnormal melanocyte proliferation	J:220623
	abnormal melanosome morphology	J:220623
	decreased foot pigmentation	J:220623
	decreased tail pigmentation	J:220623
	dilated mitochondrion	J:220623
	early cellular replicative senescence	J:220623
	oxidative stress	J:220623
Atg7tm1Tchi/Atg7tm1Tchi Tg(Vil1-cre)1000Gum/0 involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL/J	abnormal intestinal goblet cell morphology	J:206181