Dppa3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Dppa3
developmental pluripotency-associated 3
MGI:1920958

22 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Gcna^tm1.1Dcp/Y Dppa3^tm1(cre)Peli/Dppa3⁺ involves: 129S7/SvEvBrd * C57BL/6N	abnormal cell cycle	J:344952
	abnormal seminiferous tubule morphology	J:344952
	abnormal spermatogenesis	J:344952
	abnormal spermatogonia proliferation	J:344952
	abnormal testis morphology	J:344952
	normal cellular phenotype	J:344952
	decreased male germ cell number	J:344952
	decreased spermatogonia number	J:344952
	decreased testis weight	J:344952
	normal growth/size/body region phenotype	J:344952
	normal mortality/aging	J:344952
	oligozoospermia	J:344952
	testicular atrophy	J:344952
Gcna^tm1.1Dcp/Y Dppa3^tm1(cre)Peli/Dppa3⁺ Tg(Pou5f1-EGFP)2Mnn/0 involves: 129S7/SvEvBrd * C57BL/6J * C57BL/6N * CBA/CaJ	normal reproductive system phenotype	J:344952
Gcna^tm1.1Dcp/Gcna^tm1.1Dcp Dppa3^tm1(cre)Peli/Dppa3⁺ involves: 129S7/SvEvBrd * C57BL/6N	no abnormal phenotype detected	J:344952
Jak2^{tm1(JAK2)Argr}/Jak2⁺ Dppa3^tm1(cre)Peli/Dppa3⁺ involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6	abnormal protein level	J:233169
	increased chronic myelocytic leukemia incidence	J:233169
	increased hematopoietic stem cell number	J:233169
	increased leukocyte cell number	J:233169
	increased spleen weight	J:233169
	thrombocytosis	J:233169
Npm1^tm1Gsva/Npm1^tm1Gsva Dppa3^tm1(cre)Peli/Dppa3⁺ involves: 129S5/SvEvBrd * 129S7/SvEvBrd	embryonic lethality, complete penetrance	J:172071

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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