About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tbx21
T-box 21
MGI:1888984
35 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Eomestm1.1Bflu/Eomestm1.1Bflu
Tbx21tm1Glm/Tbx21tm1Glm
Tg(Cd4-cre)1Cwi/0
involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * SJL 		abnormal leukocyte migration J:163822
decreased CD4-positive, alpha-beta T cell number J:163822
decreased CD8-positive, alpha-beta T cell number J:163822
decreased interferon-gamma secretion J:163822
decreased memory T cell number J:163822
increased interleukin-4 secretion J:163822
increased interleukin-17 secretion J:163822
increased tumor incidence J:163822
Eomestm1.1Twa/?
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S6/SvEvTac * C57BL/6N 		abnormal NK cell differentiation J:210160
Eomestm1.1Twa/?
Tg(CD2-Tbx21)#Staka/?
involves: C57BL/6N 		abnormal NK cell differentiation J:210160
Eomestm1Apr/Eomes+
Tbx21tm1Srnr/Tbx21tm1Srnr
involves: C57BL/6 		decreased interferon-gamma secretion J:112679
decreased memory T cell number J:112679
decreased NK cell number J:112679
decreased NK T cell number J:112679
Eomestm1Srnr/Eomestm1Srnr
Tbx21tm1Srnr/Tbx21tm1Srnr
Tg(Cd4-cre)1Cwi/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		abnormal CD8-positive, alpha-beta T cell differentiation J:137655
abnormal immune system physiology J:137655
abnormal interleukin level J:137655
abnormal leukocyte physiology J:137655
abnormal T cell morphology J:137655
decreased CD8-positive, alpha-beta T cell number J:137655
decreased memory T cell number J:137655
increased neutrophil cell number J:137655
increased susceptibility to Riboviria infection J:137655
Ldlrtm1Her/Ldlrtm1Her
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal interleukin secretion J:96110
abnormal susceptibility to atherosclerosis J:96110
decreased IgG level J:96110
decreased interferon-gamma secretion J:96110
increased circulating cholesterol level J:96110
increased IgM level J:96110
Rag2tm1Fwa/Rag2tm1Fwa
Tbx21tm1Glm/Tbx21tm1Glm
involves: 129S/SvEv * 129S6/SvEvTac 		abnormal digestive system physiology J:141481
abnormal intestinal epithelium morphology J:141481
abnormal large intestine crypts of Lieberkuhn morphology J:141481
colitis J:141481
normal digestive/alimentary phenotype J:141481
increased tumor necrosis factor secretion J:141481
large intestinal inflammation J:141481
rectal prolapse J:141481
Tbx21tm1.1(flpe/ERT2)Gmld/Tbx21tm1.1(flpe/ERT2)Gmld
involves: 129S2/SvPas * C57BL/6 		decreased interferon-gamma secretion J:207104
Tbx21tm1Glm/Tbx21tm1Glm
Tg(TRAMP)8247Ng/0
involves: 129S6/SvEvTac * C57BL/6 		increased metastatic potential J:88093
increased prostate gland adenocarcinoma incidence J:88093
increased prostate gland tumor incidence J:88093
increased prostate intraepithelial neoplasia incidence J:88093
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory