Aicda Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aicda
activation-induced cytidine deaminase
MGI:1342279

28 phenotypes from 13 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
\Aicda^em1Jaych/\Aicda^em1Jaych involves: C57BL/6J	abnormal class switch recombination	J:305843
	abnormal lymph node cell ratio	J:305843
	abnormal Peyer's patch germinal center morphology	J:305843
	abnormal splenic cell ratio	J:305843
	normal hematopoietic system phenotype	J:305843
	increased IgM level	J:305843
\Aicda^m1Btlr/\Aicda^m1Btlr C57BL/6J-Aicda^m1Btlr	abnormal humoral immune response	J:265155
	decreased IgE level	J:265155
	increased IgM level	J:265155
\Aicda^m2Btlr/\Aicda^m2Btlr C57BL/6J-Aicda^m2Btlr	abnormal humoral immune response	J:265156
	decreased IgE level	J:265156
	increased IgM level	J:265156
\Aicda^{tm1.1(cre/ERT2)Crey}/\Aicda⁺ involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:157741
\Aicda^tm1.1Fwa/\Aicda^tm1.1Fwa involves: 129S6/SvEvTac	abnormal class switch recombination	J:209271
	abnormal somatic hypermutation frequency	J:209271
	normal immune system phenotype	J:209271
\Aicda^{tm1b(EUCOMM)Hmgu}/\Aicda^{tm1b(EUCOMM)Hmgu} C57BL/6N-Aicda^{tm1b(EUCOMM)Hmgu}/Wtsi	decreased follicular B cell number	J:211773
	decreased late germinal center B cell number	J:211773
	increased early germinal center B cell number	J:211773
	increased germinal center B cell number	J:211773
	increased leukocyte cell number	J:211773
	increased mean corpuscular hemoglobin	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
\Aicda^tm1Hon/\Aicda⁺ involves: C57BL/6 * CBA	abnormal class switch recombination	J:136224, J:141427
	abnormal somatic hypermutation frequency	J:141427
	normal immune system phenotype	J:136224
\Aicda^tm1Hon/\Aicda^tm1.1Fwa involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj	abnormal class switch recombination	J:209271
	normal immune system phenotype	J:209271
\Aicda^tm1Hon/\Aicda^tm1Hon involves: C57BL/6 * CBA	abnormal class switch recombination	J:73659, J:120658, J:141427
	abnormal somatic hypermutation frequency	J:136224, J:141427
	decreased IgA level	J:169227
	decreased IgG1 level	J:73659, J:169227
	decreased IgG2a level	J:73659
	decreased IgG2b level	J:169227
	decreased IgG3 level	J:169227
	decreased IgG level	J:169227
	increased germinal center B cell number	J:169227
	increased IgM level	J:73659, J:169227
	increased susceptibility to bacterial infection induced morbidity/mortality	J:169227
\Aicda^tm1Hon/\Aicda^tm2Mnz involves: C57BL/6 * CBA	chromosomal instability	J:136224
\Aicda^tm1Hon/\Aicda^tm2Mnz involves: C57BL/6 * CBA	normal immune system phenotype	J:136224
\Aicda^tm1Hon/\Aicda^tm3Mnz involves: C57BL/6 * CBA	abnormal class switch recombination	J:141427
\Aicda^tm1Hon/\Aicda^tm3Mnz involves: C57BL/6 * CBA	abnormal somatic hypermutation frequency	J:141427
\Aicda^tm1Hon/\Aicda^tm4Mnz involves: C57BL/6 * CBA	abnormal class switch recombination	J:141427
\Aicda^tm1Hon/\Aicda^tm4Mnz involves: C57BL/6 * CBA	abnormal somatic hypermutation frequency	J:141427
\Aicda^tm2.1Hon/\Aicda^tm2.1Hon C57BL/6-Aicda^tm2.1Hon	abnormal gut flora balance	J:169227
	abnormal somatic hypermutation frequency	J:169227
	decreased IgG1 level	J:169227
	normal immune system phenotype	J:169227
	increased germinal center B cell number	J:169227
	increased susceptibility to bacterial infection	J:169227
	increased susceptibility to bacterial infection induced morbidity/mortality	J:169227
\Aicda^tm2.1Hon/\Aicda^tm2.1Hon involves: BALB/c * C57BL/6	increased germinal center B cell number	J:169227
\Aicda^tm2Mnz/\Aicda^tm2Mnz B6.Cg-Aicda^tm2Mnz	chromosomal instability	J:136224
\Aicda^tm2Mnz/\Aicda^tm2Mnz B6.Cg-Aicda^tm2Mnz	normal immune system phenotype	J:136224
\Aicda^tm3.1Mnz/\Aicda^tm3.1Mnz involves: C57BL/6	abnormal class switch recombination	J:147109
\Aicda^tm3.1Mnz/\Aicda^tm3.1Mnz involves: C57BL/6	abnormal somatic hypermutation frequency	J:147109
\Aicda^tm3Mnz/\Aicda⁺ involves: C57BL/6 * CBA	abnormal class switch recombination	J:141427
\Aicda^tm3Mnz/\Aicda⁺ involves: C57BL/6 * CBA	abnormal somatic hypermutation frequency	J:141427
\Aicda^tm4.1Mnz/\Aicda^tm4.1Mnz involves: C57BL/6	abnormal class switch recombination	J:147109
\Aicda^tm4.1Mnz/\Aicda^tm4.1Mnz involves: C57BL/6	abnormal somatic hypermutation frequency	J:147109
\Aicda^tm4Mnz/\Aicda⁺ involves: C57BL/6 * CBA	abnormal class switch recombination	J:141427
\Aicda^tm4Mnz/\Aicda⁺ involves: C57BL/6 * CBA	abnormal somatic hypermutation frequency	J:141427

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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