Aicda^tm4.1Mnz
Targeted Allele Detail

Summary

• Symbol: Aicda^tm4.1Mnz
• Name: activation-induced cytidine deaminase; targeted mutation 4.1, Michel C Nussenzweig
• MGI ID: MGI:3839323
• Synonyms: AID T140A
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm4.1Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Threonine 140 of Exon 3 was mutated to alanine (by introducing an A95G base pair change) and a loxP-flanked neomycin resistance cassette was placed in intron 2. A B6(Cg)-Tyr^c-2J/J-derived embryonic stem cell line was used to create the mutation. The neomycin cassette was excised with Cre, leaving a single loxP site. (J:141427, J:147109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 55 strains or lines available

References

• Original: J:147109 Nussenzweig MC, Generation of an Aicda S38A knockin allele. MGI Direct Data Submission. 2009
• All: 2 reference(s)