Aicda^tm1.1Fwa
Targeted Allele Detail

Summary

• Symbol: Aicda^tm1.1Fwa
• Name: activation-induced cytidine deaminase; targeted mutation 1.1, Frederick W Alt
• MGI ID: MGI:5566773
• Synonyms: AID^S38A
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^tm1.1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209271
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 2 was replaced with a modified exon 2 in which the nucleotide substitutions (AGT to GCT) result in the amino acid substitution of alanine for serine at position 38 (S38A). This mutation is predicted not to interact with endogenous replication protein A. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the modified exon 2. (J:209271)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 55 strains or lines available

References

• Original: J:209271 Cheng HL, et al., Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2717-22
• All: 4 reference(s)