About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm1.1Fwa
targeted mutation 1.1, Frederick W Alt
MGI:5566773
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aicdatm1.1Fwa/Aicdatm1.1Fwa involves: 129S6/SvEvTac MGI:5566787
ht2
 		Aicdatm1Hon/Aicdatm1.1Fwa involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj MGI:5566788


Genotype
MGI:5566787
hm1
Allelic
Composition		 Aicdatm1.1Fwa/Aicdatm1.1Fwa
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1.1Fwa mutation (0 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209271 )
N
• mice exhibit normal numbers of splenic B and T cells and response to activation
abnormal class switch recombination ( J:209271 )
• decreased class switch recombination to IgG1 and IgG3
abnormal somatic hypermutation frequency ( J:209271 )
• reduced in Peyer's patch B cell

hematopoietic system
abnormal class switch recombination ( J:209271 )
• decreased class switch recombination to IgG1 and IgG3
abnormal somatic hypermutation frequency ( J:209271 )
• reduced in Peyer's patch B cell




Genotype
MGI:5566788
ht2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1.1Fwa
Genetic
Background		 involves: 129S/SvEv * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1.1Fwa mutation (0 available); any Aicda mutation (57 available)
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:209271 )
N
• mice exhibit normal numbers of splenic B and T cells and response to activation
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3

hematopoietic system
abnormal class switch recombination ( J:209271 )
• severely decreased class switch recombination to IgG1 and IgG3




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory