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Targeted Allele Detail
Symbol: Aicdatm1.1(cre/ERT2)Crey
Name: activation-induced cytidine deaminase; targeted mutation 1.1, Claude-Agnes Reynaud
MGI ID: MGI:4437052
Synonyms: AID-Cre-ERT2
Gene: Aicda  Location: Chr6:122530768-122541139 bp, + strand  Genetic Position: Chr6, 57.65 cM, cytoband F2
Alliance: Aicdatm1.1(cre/ERT2)Crey page
Germline Transmission:  Earliest citation of germline transmission: J:157741
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
Aicdatm1.1(cre/ERT2)Crey expression driven by 1 gene
Mutation detailsA targeting construct was designed to insert a cre/ERT2 sequence, an SV40 polyA site, and a floxed neo selection cassette into the Aicda locus, replacing exon 2 and fusing with sequence encoding the first 4 amino acids, including 4 bases downstream of the exon 2 splice site. The splice acceptor site of Aicda intron 2-3 was mutated to prevent splicing events that could eliminate the cre/ERT2 sequence. E14.1 ES cells were electroporated with the linearized vector. Recombinant clones were transiently transfected with a cre-expressing vector to excise the neo cassette. (J:157741)
 Tissue activity of this recombinase allele
Driver: Aicda (mouse)
Summary of all recombinase alleles driven by Aicda.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Aicda Mutation:  55 strains or lines available
Original:  J:157741 Dogan I, et al., Multiple layers of B cell memory with different effector functions. Nat Immunol. 2009 Dec;10(12):1292-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory