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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkag2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
MGI:1336153
47 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkag2em1(IMPC)J/Prkag2em1(IMPC)J
C57BL/6NJ-Prkag2em1(IMPC)J/Mmjax 		decreased exploration in new environment J:211773
decreased thigmotaxis J:211773
increased grip strength J:211773
Prkag2tm1.1Geno/Prkag2tm1.1Geno
B6J.129S(Cg)-Prkag2tm1.1Geno 		abnormal inflammatory response J:235379
abnormal pancreatic beta cell physiology J:235379
abnormal sinoatrial node conduction J:256296
abnormal sinoatrial node morphology J:256296
decreased cardiac muscle contractility J:256296
decreased circulating insulin level J:235379
decreased heart rate J:256296
hepatic steatosis J:235379
impaired glucose tolerance J:235379
increased body fat mass J:235379
increased cardiac muscle glycogen level J:256296
increased susceptibility to age related obesity J:235379
increased white fat cell size J:235379
insulin resistance J:235379
polyphagia J:235379
sinus bradycardia J:256296
white adipose tissue inflammation J:235379
Prkag2tm1.1Geno/Prkag2tm1.1Geno
Edil3Tg(Sox2-cre)1Amc/Edil3+
B6.Cg-Prkag2tm1.1Geno Edil3Tg(Sox2-cre)1Amc 		abnormal sinoatrial node conduction J:256296
increased heart rate J:256296
Prkag2tm2.1Mrl/?
C57BL/6-Prkag2tm2.1Mrl/Tac 		abnormal sinus arrhythmia J:237375
cardiac hypertrophy J:237375
decreased circulating cholesterol level J:237375
decreased circulating free fatty acids level J:237375
decreased circulating triglyceride level J:237375
decreased heart rate J:237375
decreased susceptibility to diet-induced hepatic steatosis J:237375
decreased susceptibility to diet-induced obesity J:237375
improved glucose tolerance J:237375
increased insulin sensitivity J:237375
increased skeletal muscle glycogen level J:237375
shortened PQ interval J:237375
shortened PR interval J:237375
shortened RR interval J:237375
ventricular premature beat J:237375
Prkag2tm3.1Mrl/?
C57BL/6-Prkag2tm3.1Mrl/Tac 		abnormal kidney morphology J:237375
abnormal kidney papilla morphology J:237375
abnormal renal tubule morphology J:237375
abnormal sinus arrhythmia J:237375
abnormal urine albumin level J:237375
cardiac hypertrophy J:237375
decreased circulating cholesterol level J:237375
decreased circulating free fatty acids level J:237375
decreased circulating triglyceride level J:237375
decreased food intake J:237375
decreased heart rate J:237375
decreased susceptibility to diet-induced hepatic steatosis J:237375
decreased susceptibility to diet-induced obesity J:237375
improved glucose tolerance J:237375
increased cardiac muscle glycogen level J:237375
increased circulating ketone body level J:237375
increased insulin sensitivity J:237375
increased kidney apoptosis J:237375
increased kidney glycogen level J:237375
increased skeletal muscle glycogen level J:237375
increased urine protein level J:237375
kidney cyst J:237375
kidney inflammation J:237375
proteinosis J:237375
shortened PQ interval J:237375
shortened PR interval J:237375
shortened RR interval J:237375
ventricular premature beat J:237375
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory