94 phenotypes from 6 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lyz2tm1(cre)Ifo/Lyz2+ Pikfyvetm1b(EUCOMM)Hmgu/Pikfyvetm1b(EUCOMM)Hmgu involves: 129P2/OlaHsd * C57BL/6N	abnormal alveolar macrophage morphology	J:244776
	abnormal alveolar macrophage physiology	J:244776
	decreased alveolar macrophage number	J:244776
	decreased regulatory T cell number	J:244776
	normal immune system phenotype	J:244776
	increased eosinophil cell number	J:244776
	increased interleukin-4 secretion	J:244776
	increased interleukin-13 secretion	J:244776
	increased susceptibility to type I hypersensitivity reaction	J:244776
PikfyveGt(AT0926)Wtsi/PikfyveGt(AT0926)Wtsi involves: 129P2/OlaHsd * C57BL/6	abnormal atrium myocardium morphology	J:190368
	abnormal brain morphology	J:190368
	abnormal brainstem morphology	J:190368
	abnormal cerebellum deep nucleus morphology	J:190368
	abnormal dorsal root ganglion morphology	J:190368
	abnormal embryonic/fetal subventricular zone morphology	J:190368
	abnormal heart morphology	J:190368
	abnormal lipid level	J:190368
	abnormal locomotor behavior	J:190368
	abnormal midbrain morphology	J:190368
	abnormal neuron morphology	J:190368
	abnormal pons morphology	J:190368
	abnormal pulmonary alveolar system morphology	J:190368
	abnormal renal tubule morphology	J:190368
	abnormal spinal cord morphology	J:190368
	abnormal spleen morphology	J:190368
	abnormal superior vena cava morphology	J:190368
	abnormal thymus morphology	J:190368
	abnormal ventricle myocardium morphology	J:190368
	brain vacuoles	J:190368
	decreased birth body size	J:190368
	decreased body weight	J:190368
	decreased brain weight	J:190368
	dilated heart right ventricle	J:190368
	increased heart right atrium size	J:190368
	kidney degeneration	J:190368
	perinatal lethality, incomplete penetrance	J:190368
	postnatal lethality, complete penetrance	J:190368
	pulmonary vascular congestion	J:190368
	small heart	J:190368
	spleen hypoplasia	J:190368
	thymus hypoplasia	J:190368
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi involves: C57BL/6	decreased DNA replication	J:171129
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi involves: C57BL/6	no abnormal phenotype detected	J:199213
Pikfyvetm1.1Ashi/Pikfyvetm1.1Ashi Tg(Ckm-cre)28Arte/0 involves: C57BL/6	decreased heart weight	J:199213
	decreased muscle cell glucose uptake	J:199213
	normal homeostasis/metabolism phenotype	J:199213
	impaired glucose tolerance	J:199213
	increased adipocyte glucose uptake	J:199213
	increased body weight	J:199213
	increased circulating insulin level	J:199213
	increased circulating triglyceride level	J:199213
	increased fat cell size	J:199213
	increased gonadal fat pad weight	J:199213
	increased renal fat pad weight	J:199213
	increased susceptibility to age related obesity	J:199213
	increased total body fat amount	J:199213
	insulin resistance	J:199213
	normal muscle phenotype	J:199213
Pikfyvetm1.2Ashi/Pikfyve+ involves: C57BL/6	abnormal cell morphology	J:171129
Pikfyvetm1.2Ashi/Pikfyvetm1.2Ashi involves: C57BL/6	abnormal blastocoele morphology	J:171129
	abnormal blastocyst morphology	J:171129
	abnormal inner cell mass morphology	J:171129
	abnormal trophectoderm morphology	J:171129
	absent blastocoele	J:171129
	embryonic lethality before implantation, complete penetrance	J:171129
	embryonic lethality before implantation, incomplete penetrance	J:171129
Pikfyvetm1Tssk/Pikfyvetm1Tssk involves: 129P2/OlaHsd * C57BL/6	abnormal visceral endoderm morphology	J:193689
	abnormal visceral endoderm physiology	J:193689
	decreased embryo size	J:193689
	embryonic growth arrest	J:193689
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:193689
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk Tg(Tyr-cre/ERT2)13Bos/0 involves: C57BL/6 * C57BL/6J	abnormal coat/hair pigmentation	J:262141
	abnormal endosome to melanosome transport	J:262141
	abnormal hair follicle melanocyte morphology	J:262141
	abnormal melanosome maturation	J:262141
	diluted coat color	J:262141
	reduced hair shaft melanin granule number	J:262141
Pikfyvetm2.1Tssk/Pikfyvetm2.1Tssk Tg(Vil1-cre)20Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal circulating enzyme level	J:193689
	abnormal enterocyte morphology	J:193689
	abnormal small intestinal microvillus morphology	J:193689
	decreased body weight	J:193689
	decreased circulating free fatty acids level	J:193689
	decreased circulating serum albumin level	J:193689
	decreased circulating total protein level	J:193689
	decreased small intestinal microvillus size	J:193689
	diarrhea	J:193689
	disheveled coat	J:193689
	hunched posture	J:193689
	intestinal fibrosis	J:193689
	intestinal inflammation	J:193689
	lethality, incomplete penetrance	J:193689
	lethargy	J:193689
	melena	J:193689
	premature death	J:193689
	prenatal lethality, incomplete penetrance	J:193689