Pikfyvetm1.2Ashi
Targeted Allele Detail
|
Symbol: |
Pikfyvetm1.2Ashi |
Name: |
phosphoinositide kinase, FYVE type zinc finger containing; targeted mutation 1.2, Assia Shisheva |
MGI ID: |
MGI:4949709 |
Gene: |
Pikfyve Location: Chr1:65225842-65317854 bp, + strand Genetic Position: Chr1, 32.94 cM, cytoband C3
|
Alliance: |
Pikfyvetm1.2Ashi page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:171129
|
Parent Cell Line: |
Bruce 4 (ES Cell)
|
Strain of Origin: |
B6.Cg-Thy1a
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: Cre-mediated recombination removed exon 6, which encodes the FYVE domain. This deletion is predicted to cause a frameshift and early stop codon. A 2-fold reduction in protein production was confirmed by western blot analysis of heterozygous mouse embryonic fibroblasts.
(J:171129)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Pikfyve Mutation: |
114 strains or lines available
|
|
Original: |
J:171129 Ikonomov OC, et al., The Phosphoinositide Kinase PIKfyve Is Vital in Early Embryonic Development: PREIMPLANTATION LETHALITY OF PIKfyve-/- EMBRYOS BUT NORMALITY OF PIKfyve+/- MICE. J Biol Chem. 2011 Apr 15;286(15):13404-13 |
All: |
1 reference(s) |
|