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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cx3cr1
C-X3-C motif chemokine receptor 1
MGI:1333815
50 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Bres/Apoetm1Bres
Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		decreased susceptibility to atherosclerosis J:81822
impaired macrophage chemotaxis J:81822
Apoetm1Unc/Apoetm1Unc
Cx3cr1tm1Zm/Cx3cr1+
B6.129-Apoetm1Unc Cx3cr1tm1Zm 		decreased susceptibility to atherosclerosis J:103047
Apoetm1Unc/Apoetm1Unc
Cx3cr1tm1Zm/Cx3cr1tm1Zm
B6.129-Apoetm1Unc Cx3cr1tm1Zm 		decreased susceptibility to atherosclerosis J:103047
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J 		abnormal amacrine cell morphology J:200877
abnormal Bruch membrane morphology J:200877
abnormal macrophage physiology J:200877
abnormal microglial cell morphology J:200877
abnormal Muller cell morphology J:200877
abnormal photoreceptor inner segment morphology J:200877
abnormal retina morphology J:200877
abnormal retina pigmentation J:200877
disorganized photoreceptor outer segment J:200877
increased microglial cell activation J:200877
increased susceptibility to age-related retinal degeneration J:200877
retina photoreceptor degeneration J:200877
retina pigment epithelium atrophy J:200877
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Zm/Cx3cr1tm1Zm
involves: 129 * 129S4/SvJae 		abnormal Bruch membrane morphology J:126935
abnormal retina morphology J:126935
abnormal retina pigment epithelium morphology J:126935
abnormal retina pigmentation J:126935
choroidal neovascularization J:126935
decreased litter size J:126935
disorganized photoreceptor outer segment J:126935
retina deposits J:126935
retina photoreceptor degeneration J:126935
retina pigment epithelium atrophy J:126935
retina pigment epithelium hyperplasia J:126935
variable depigmentation J:126935
Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal leukocyte physiology J:166664
decreased susceptibility to experimental autoimmune encephalomyelitis J:166664
Ccr2tm2.1Ifc/Ccr2tm2.1Ifc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal leukocyte physiology J:166664
decreased susceptibility to experimental autoimmune encephalomyelitis J:166664
Cd1d1tm1Luc/Cd1d1tm1Luc
Cx3cr1tm1Litt/Cx3cr1tm1Litt
B6.129-Cd1d1tm1Luc Cx3cr1tm1Litt 		decreased NK cell number J:129712
increased susceptibility to experimental autoimmune encephalomyelitis J:129712
paralysis J:129712
Cx3cr1tm1.1(cre)Jung/Cx3cr1+
Sqorem1Chji/Sqorem1Chji
B6(Cg)-Sqorem1Chji Cx3cr1tm1.1(cre)Jung 		impaired behavioral response to xenobiotic J:314187
Cx3cr1tm1Litt/Cx3cr1+
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		abnormal microglial cell morphology J:159680
abnormal microglial cell physiology J:159680
neuron degeneration J:159680
Cx3cr1tm1Litt/Cx3cr1tm1Litt
H2-Ab1b-tm1Hpl/H2-Ab1+
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal response to infection J:95694
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA 		normal nervous system phenotype J:159680
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Tg(SOD1*G93A)1Gur/0
involves: 129P2/OlaHsd * C57BL/6 * SJL 		decreased grip strength J:110266
decreased neuron number J:110266
increased susceptibility to weight loss J:110266
premature death J:110266
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
Vps35Gt(RRK261)Byg/Vps35Gt(RRK261)Byg
involves: 129P2/OlaHsd * C57BL/6 		decreased cerebral infarct size J:292365
decreased interleukin-1 beta secretion J:292365
decreased interleukin-6 secretion J:292365
decreased neuron apoptosis J:292365
decreased susceptibility to induced morbidity/mortality J:292365
decreased tumor necrosis factor secretion J:292365
increased interleukin-4 secretion J:292365
increased interleukin-10 secretion J:292365
increased macrophage cell number J:292365
increased transforming growth factor beta level J:292365
microgliosis J:292365
Cx3cr1tm3(Hbegf)Litt/Cx3cr1tm3(Hbegf)Litt
Tg(Itgax-cre)1-1Reiz/?
involves: 129P2/OlaHsd * C57BL/6 * CBA 		decreased susceptibility to bacterial infection J:210086
Gpr35em2Niess/Gpr35em2Niess
Cx3cr1tm2.1(cre/ERT2)Litt/Cx3cr1+
involves: 129P2/OlaHsd * C57BL/6N 		abnormal corticosterone level J:300275
decreased colon length J:300275
increased susceptibility to induced colitis J:300275
increased susceptibility to weight loss J:300275
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory